Pre-exposure prophylaxis (PrEP) is an effective HIV prevention method, but it has been underutilized by women. Anticipated stigma regarding use of PrEP is a contributing factor in the underutilization of this prevention strategy. The current study explored the relationships among PrEP stigma, sex risk (i.e., inconsistent condom use, condomless sex with persons of unknown serostatus, or sex in exchange for money or drugs), substance use, attitudes toward HIV testing, and medical mistrust. Participants were 106 primarily ethnic-minority women who reported recent substance use and agreed to participate in a study exploring HIV prevention attitudes. Within this sample, the majority of participants had one or more CDC-defined PrEP indications. Findings indicate that medical mistrust was associated with perceived PrEP stereotypes and HIV testing attitudes. These results provide some insight into reasons for low PrEP uptake among women at risk for HIV. Implications for HIV prevention with women are discussed.

暴露前预防 (PrEP) 是一种有效的 HIV 预防方法，但女性并未充分利用它。关于使用 PrEP 的预期耻辱是导致该预防策略未充分利用的一个因素。目前的研究探讨了 PrEP 的耻辱、性风险（即，不一致的安全套使用、与未知血清状态的人无安全套性交、或以性换取金钱或药物）、物质使用、对 HIV 检测的态度和医疗不信任之间的关系。参与者是 106 名主要是少数族裔的女性，她们报告了最近的物质使用情况，并同意参与一项探讨艾滋病毒预防态度的研究。在这个样本中，大多数参与者有一个或多个 CDC 定义的 PrEP 适应症。调查结果表明，医学上的不信任与感知到的 PrEP 刻板印象和 HIV 检测态度有关。这些结果为了解有 HIV 感染风险的女性 PrEP 摄取率低的原因提供了一些见解。讨论了对女性艾滋病毒预防的影响。