With oral antiretroviral pre-exposure prophylaxis (PrEP) rollout expanding to include adolescents in South Africa, research is needed to better understand perceptions of PrEP acceptability among adolescents and clinical service providers. We conducted an exploratory mixed-methods study among 57 adolescents, 16–17 years of age, living with and without HIV, and 25 clinical service providers in Cape Town, South Africa from 2015 to 2016. Cross-sectional survey and semi-structured qualitative interview data were used to explore (1) willingness to use PrEP and support partner PrEP use among adolescents living with and without HIV, (2) willingness to prescribe or support prescription of PrEP among service providers, and (3) perceptions of barriers and facilitators to PrEP implementation and interpretations of PrEP efficacy messaging for adolescent HIV prevention among all participants. Acceptability of PrEP among participants was high. Support for PrEP uptake was linked to messages that positively framed PrEP’s protection potential (i.e., success- versus failure-framed messaging) among both adolescents and providers. Adolescents living without HIV endorsed high willingness to use PrEP and adolescents living with HIV endorsed high support for partner PrEP use. However, both groups noted that potential side effects, stigma, and PrEP’s partial efficacy may hinder uptake. Clinical service providers endorsed PrEP for sexually active adolescents and shared stigma and efficacy concerns. Further, service providers expressed desire for adolescent-tailored training and integration of PrEP delivery into primary care and family planning services. Efforts to educate adolescents and service providers about PrEP should consider how message framing may influence acceptability. Community PrEP education and adolescent-friendly delivery should be prioritized to alleviate predicted PrEP stigma and facilitate uptake.

随着口服抗逆转录病毒暴露前预防 (PrEP) 的推广范围扩大到南非的青少年，需要进行研究以更好地了解青少年和临床服务提供者对 PrEP 可接受性的看法。2015 年至 2016 年，我们对南非开普敦的 57 名 16-17 岁感染或未感染艾滋病毒青少年以及 25 名临床服务提供者进行了一项探索性混合方法研究。横断面调查和半结构化定性研究访谈数据用于探讨（1）感染和未感染艾滋病毒的青少年使用 PrEP 的意愿以及支持合作伙伴 PrEP 使用的意愿，（2）服务提供者开具或支持 PrEP 处方的意愿，以及（3）对障碍和促进因素的看法PrEP 的实施以及对所有参与者中预防青少年艾滋病毒的 PrEP 功效信息的解释。参与者对 PrEP 的接受度很高。对 PrEP 吸收的支持与在青少年和提供者中积极阐述 PrEP 保护潜力的信息（即成功与失败的信息）相关。未感染艾滋病毒的青少年非常愿意使用 PrEP，而感染艾滋病毒的青少年则非常支持伴侣使用 PrEP。然而，两个小组都指出，潜在的副作用、耻辱和 PrEP 的部分功效可能会阻碍吸收。临床服务提供者认可对性活跃青少年进行 PrEP，但也存在耻辱和疗效问题。此外，服务提供者表示希望进行针对青少年的培训并将 PrEP 服务纳入初级保健和计划生育服务。对青少年和服务提供者进行 PrEP 教育时应考虑信息框架如何影响可接受性。应优先考虑社区 PrEP 教育和青少年友好型教育，以减轻预期的 PrEP 耻辱并促进接受。