Pharmacogenomic insights provide an opportunity to optimize medication dosing regimens and patient outcomes. However, the potential for interindividual genomic variability to guide medication dosing and toxicity monitoring is not yet standard of care. In this review, we present advances for the thiopurines, anthracyclines and vincristine and provide perspectives on the actionability of pharmacogenomic guidance in the future.

中文翻译：

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药物基因组学对精准儿科肿瘤学的见解。

药物基因组学见解提供了优化药物剂量方案和患者结果的机会。然而，个体间基因组变异指导药物剂量和毒性监测的潜力尚未成为护理标准。在这篇综述中，我们介绍了硫嘌呤类药物、蒽环类药物和长春新碱的进展，并就未来药物基因组学指导的可操作性提供了展望。