Nonmalignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin-rich thrombus,Hepatology

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Nonmalignant portal vein thrombi in patients with cirrhosis consist of intimal fibrosis with or without a fibrin-rich thrombus
Hepatology ( IF 13.5 ) Pub Date : 2021-09-24 , DOI: 10.1002/hep.32169
Ellen G Driever ₁ , Fien A von Meijenfeldt ₁ , Jelle Adelmeijer ₁ , Robbert J de Haas ₂ , Marius C van den Heuvel ₃ , Chandrasekaran Nagasami ₄ , John W Weisel ₄ , Constantino Fondevila ₅ , Robert J Porte ₆ , Anabel Blasi ₇ , Nigel Heaton ₈ , Stephen Gregory ₉ , Pauline Kane ₉ , William Bernal _{10,

11} , Yoh Zen ₁₂ , Ton Lisman _{1,

6}

Affiliation

Surgical Research LaboratoryDepartment of SurgeryUniversity Medical Center GroningenGroningenthe Netherlands.
Department of RadiologyUniversity Medical Center GroningenGroningenthe Netherlands.
Department of Pathology and Medical BiologyUniversity Medical Center GroningenGroningenthe Netherlands.
Department of Cell and Developmental BiologyUniversity of Pennsylvania School of MedicinePhiladelphiaPennsylvaniaUSA.
Department of SurgeryHospital ClínicInstitute d'Investigacions Biomèdica Agustí Pi i Sunyer (IDIBAPS)University of BarcelonaBarcelonaSpain.
Department of SurgerySection of Hepatobiliary Surgery and Liver TransplantationUniversity Medical Center GroningenGroningenthe Netherlands.
Anesthesiology DepartmentHospital ClínicInstitute d'Investigacions Biomèdica Agustí Pi i Sunyer (IDIBAPS)University of BarcelonaBarcelonaSpain.
Liver Transplant SurgeryInstitute of Liver StudiesKing's College HospitalLondonUK.
Department of RadiologyKing's College HospitalLondonUK.
Liver Intensive Care UnitInstitute of Liver StudiesKing's College HospitalLondonUK.
Institute of Liver StudiesKing's College HospitalLondonUK.
Department of PathologyInstitute of Liver StudiesKing's College HospitalLondonUK.

Portal vein thrombosis (PVT) is a common complication of cirrhosis. The exact pathophysiology remains largely unknown, and treatment with anticoagulants does not lead to recanalization of the portal vein in all patients. A better insight into the structure and composition of portal vein thrombi may assist in developing strategies for the prevention and treatment of PVT.

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