T lymphocytes (T cells) are major players of the adaptive immune response. Naive T cells are primed in the presence of cytokines, leading to polarization into distinct T-cell subsets with specific functions. These subsets are classified based on their T-cell receptor profile, expression of transcription factors, surface cytokine and chemokine receptors, and their cytokine production, which together determine their specific function. This review provides an overview of the various T-cell subsets and their function in several inflammatory skin disorders ranging from allergic inflammation to skin tumors. Moreover, we highlight similarities of T-cell responses across different skin disorders, demonstrating the presence of similar and opposing functions for the different T-cell subsets. Finally, we discuss the effects of currently available and promising therapeutic approaches to harness T cells in inflammatory skin diseases for which efficacy next to unwanted side effects provide new insights into the pathophysiology of skin disorders.

中文翻译：

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皮肤中的 T 细胞亚群及其在炎症性皮肤病中的作用

T淋巴细胞（T细胞）是适应性免疫反应的主要参与者。幼稚 T 细胞在细胞因子存在的情况下被激发，导致极化成具有特定功能的不同 T 细胞亚群。这些亚群根据它们的 T 细胞受体谱、转录因子、表面细胞因子和趋化因子受体的表达以及它们的细胞因子产生进行分类，这些共同决定了它们的特定功能。本综述概述了各种 T 细胞亚群及其在从过敏性炎症到皮肤肿瘤等多种炎症性皮肤病中的功能。此外，我们强调了不同皮肤疾病中 T 细胞反应的相似性，证明了不同 T 细胞亚群存在相似和相反的功能。最后，