Cognitive theories have been proposed to clarify the causes and symptoms of dyslexia. However, correlations between local network parameters of white matter connectivity and literacy skills remain poorly known. An unbiased hypothesis-free approach was adopted to examine the correlations between literacy symptoms (reading and spelling) and hub-based white matter networks' connectivity parameters [nodal degree fractional anisotropy (FA) values] of 90 brain regions based on Anatomical Atlas Labels (AAL) in a group of French children with dyslexia aged 9–14 years. Results revealed that the higher the right fusiform gyrus's (FFG) nodal degree FA values, the lower the reading accuracy for words and pseudowords in dyslexic children. The results indicate that the severity of word/pseudoword reading symptoms in dyslexia relates to a white matter network centered around the right FFG. The negative correlation between right FFG network connectivity and reading accuracy, in particular pseudoword reading accuracy, suggests that right FFG represents a maladaptive compensation towards a general orthography-to-phonology decoding ability in developmental dyslexia.

已经提出认知理论来阐明阅读障碍的原因和症状。然而，白质连接的本地网络参数与读写能力之间的相关性仍然鲜为人知。采用无偏假设的方法来检查识字症状（阅读和拼写）与基于中心的白质网络的连接参数 [节点度分数各向异性 (FA) 值] 基于解剖图谱标签的 90 个大脑区域之间的相关性。 AAL) 在一组 9-14 岁的法国阅读障碍儿童中。结果表明，右侧梭状回（FFG）结度FA值越高，阅读障碍儿童的单词和伪词阅读准确率越低。结果表明，阅读障碍中单词/伪词阅读症状的严重程度与以右侧 FFG 为中心的白质网络有关。右侧 FFG 网络连通性与阅读准确度（尤其是伪词阅读准确度）之间的负相关表明，右侧 FFG 代表了对发育性阅读障碍中一般正字法到语音解码能力的适应不良补偿。