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Progressive macrographia for block letter writing: A case study
Cortex ( IF 3.6 ) Pub Date : 2021-09-24 , DOI: 10.1016/j.cortex.2021.09.002
Carlo Semenza 1 , Serena De Pellegrin 2 , Silvia Facchini 3 , Diego Cecchin 4 , Renzo Manara 5 , Tim Shallice 6 , Antonino Vallesi 7
Affiliation  

“Macrographia”, a relatively rare symptom generally following cerebellar diseases, consists of an abnormally large handwriting. The case reported in the present investigation shows several outstanding features. First, it is of the progressive variety, letters increase in size as one goes through the word towards the lower-right portion of space. Moreover, it is limited to one allographic variety, that is, block letters. This phenomenon is previously unreported, all allographic varieties being usually equally affected. Finally, no prominent cerebellar or basal ganglia abnormality could be demonstrated with structural MRI or PET. From a cognitive point of view, a peculiar combination of spatial attention, executive function and working memory deficits is proposed to account for the progressive misalignment and elongation of individual letters when specifically writing in block prints. From an anatomical perspective, the pattern of multifocal lesions, encompassing multiple cortical areas in both hemispheres and the corpus callosum, may support this multi-componential interpretation of the reported phenomenon.



中文翻译:

正楷书写的渐进式大写法:案例研究

“Macrographia”是一种相对罕见的症状,通常在小脑疾病之后出现,由异常大的笔迹组成。本次调查报告的案件有几个突出的特点。首先,它是渐进式的,字母的大小随着一个单词向空间的右下部分移动而增加。此外,它仅限于一种同种异形体,即大写字母。这种现象以前没有报道过,所有同种异形品种通常都受到同样的影响。最后,结构 MRI 或 PET 未发现明显的小脑或基底节异常。从认知的角度来看,空间注意力的特殊组合,建议执行功能和工作记忆缺陷来解释个别字母在专门用块印刷品书写时的渐进性错位和伸长。从解剖学的角度来看,多灶性病变的模式,包括半球和胼胝体的多个皮质区域,可能支持对所报道现象的这种多成分解释。

更新日期:2021-10-12
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