Abstract

Objectives

This study aimed to systematically review the literature on laboratory researches and statistically determine the influence of mineralizing strategy on the dentin bond stability.

Methods

The search was conducted in PubMed/MEDLINE, Web of Science, EMBASE, and SCOPUS according to the PRISM guidelines. From 2200 possible eligible articles, 50 were selected for full-text analysis, and 15 were included in the systematic review. Two authors independently selected the studies, extracted the data, and assessed the risk of bias. Bond strength analysis was conducted by RevMan5.3 with random effects model (α = 0.05), comparing control (without mineralizing strategy) and experimental groups (mineralizing strategy).

Results

Fifteen included trials concerned 46 comparisons between experimental groups adopting mineralizing strategy and control groups. Mineralization strategy reduced the dentin bond strength loss after aging. Although non-significant, the aging bond strength was higher than traditional bond methods (p = 0.07), the improvement was significant in pretreat (p = 0.01) and etch and rinse subgroup (p = 0.04). A significant reduction was found in immediate bond strength was associated with the use of mineralization strategy (p = 0.003). The majority of included studies were scored high risk of bias, high heterogeneity was presented in the meta-analyses.

Conclusion

Mineralization strategy reduced the dentin bond strength loss after aging. Bond strength after aging tends to be increased by mineralization strategy when used as a pretreat procedure, and in etch and rinse adhesive system. However, the mineralization strategy reduced the immediate dentin bond strength and didn’t influence aging bond strength in total.

中文翻译：

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牙本质键稳定性的矿化策略：体外研究和荟萃分析的系统评价

摘要

目标

本研究旨在系统回顾实验室研究文献，并统计确定矿化策略对牙本质粘合稳定性的影响。

方法

根据 PRISM 指南，在 PubMed/MEDLINE、Web of Science、EMBASE 和 SCOPUS 中进行了搜索。从 2200 篇可能符合条件的文章中，选择了 50 篇进行全文分析，其中 15 篇被纳入系统评价。两位作者独立选择研究、提取数据并评估偏倚风险。结合强度分析采用RevMan5.3随机效应模型（α  =0.05），比较对照组（无矿化策略）和实验组（矿化策略）。

结果

15 项试验涉及采用矿化策略的实验组和对照组之间的 46 次比较。矿化策略减少了老化后牙本质粘合强度的损失。虽然不显着，但老化粘合强度高于传统粘合方法 ( p = 0.07)，但预处理 ( p  = 0.01) 和蚀刻和冲洗亚组 ( p  = 0.04) 的改善显着。发现直接粘合强度显着降低与使用矿化策略有关（p  = 0.003）。大多数纳入的研究被评为高偏倚风险，荟萃分析中呈现高异质性。

结论

矿化策略减少了老化后牙本质粘合强度的损失。当用作预处理程序时，以及在蚀刻和冲洗粘合剂系统中，老化后的粘合强度往往会通过矿化策略增加。然而，矿化策略降低了即刻牙本质粘合强度，并且总体上不影响老化粘合强度。