Green tea, a widely consumed beverage in Asia, contains green tea catechins effective against obesity, especially epigallocatechin-3-O-gallate (EGCG), but must be consumed in an impractically huge amount daily to elicit its biological effect. Meanwhile, citrus polyphenols have various physiological effects that could enhance EGCG functionality. Here we investigated the antiobesity effect of a combination of EGCG and α-glucosyl hesperidin, a citrus polyphenol, at doses that have not been previously reported to exert antiobesity effects by themselves in any clinical trial. In a randomized, placebo-controlled, double-blinded, and parallel-group-designed clinical trial, 60 healthy Japanese males and females aged 30–75 years consumed green tea combined with α-glucosyl hesperidin (GT-gH), which contained 178 mg α-glucosyl hesperidin and 146 mg EGCG, for 12 weeks. Physical, hematological, blood biochemical, and urine examinations showed that GT-gH is safe to use. At week 12, GT-gH prevented weight gain and reduced body mass index (BMI) compared with the placebo. Especially in those aged < 50 years, triglyceride and body fat percentage decreased at week 6, visceral fat level and body fat percentage decreased at week 12; body weight, BMI, and blood LDL/HDL ratio also decreased. In conclusion, taking GT-gH prevents weight gain, and the antiobesity effect of GT-gH was more pronounced in people aged < 50 years.

绿茶是亚洲广泛饮用的饮料，含有绿茶儿茶素，尤其是对肥胖症有效的表没食子儿茶素-3- O-没食子酸酯（EGCG），但必须每天以不切实际的大量消耗来引发其生物效应。同时，柑橘多酚具有多种生理作用，可以增强 EGCG 的功能。在这里，我们研究了 EGCG 和 α-葡萄糖基橙皮苷（一种柑橘多酚）的组合的抗肥胖作用，其剂量以前没有报道过在任何临床试验中单独发挥抗肥胖作用。在一项随机、安慰剂对照、双盲和平行组设计的临床试验中，60 名年龄在 30-75 岁的健康日本男性和女性饮用绿茶联合 α-葡萄糖基橙皮苷 (GT-gH)，其中含有 178 mg α-葡萄糖基橙皮苷和 146 mg EGCG，持续 12 周。物理、血液学、血液生化和尿液检查表明 GT-gH 可以安全使用。在第 12 周，与安慰剂相比，GT-gH 可防止体重增加并降低体重指数 (BMI)。尤其是<50岁的人，第6周甘油三酯和体脂百分比下降，第12周内脏脂肪水平和体脂百分比下降；体重、BMI 和血液 LDL/HDL 比率也下降。总之，服用 GT-gH 可以防止体重增加，并且 GT-gH 的抗肥胖作用在 <50 岁的人群中更为明显。