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Brain adiponectin signaling controls peripheral insulin response in Drosophila
Nature Communications ( IF 16.6 ) Pub Date : 2021-09-24 , DOI: 10.1038/s41467-021-25940-6
Nathalie Arquier 1 , Marianne Bjordal 2 , Philippe Hammann 3 , Lauriane Kuhn 3 , Pierre Léopold 4
Affiliation  

The brain plays a key role in energy homeostasis, detecting nutrients, metabolites and circulating hormones from peripheral organs and integrating this information to control food intake and energy expenditure. Here, we show that a group of neurons in the Drosophila larval brain expresses the adiponectin receptor (AdipoR) and controls systemic growth and metabolism through insulin signaling. We identify glucose-regulated protein 78 (Grp78) as a circulating antagonist of AdipoR function produced by fat cells in response to dietary sugar. We further show that central AdipoR signaling inhibits peripheral Juvenile Hormone (JH) response, promoting insulin signaling. In conclusion, we identify a neuroendocrine axis whereby AdipoR-positive neurons control systemic insulin response.



中文翻译:

脑脂联素信号控制果蝇的外周胰岛素反应

大脑在能量稳态中起着关键作用,它检测来自外周器官的营养物质、代谢物和循环激素,并整合这些信息来控制食物摄入和能量消耗。在这里,我们展示了果蝇幼虫大脑中的一组神经元表达脂联素受体 (AdipoR) 并通过胰岛素信号传导控制全身生长和代谢。我们将葡萄糖调节蛋白 78 (Grp78) 鉴定为脂肪细胞响应膳食糖产生的 AdipoR 功能的循环拮抗剂。我们进一步表明中枢 AdipoR 信号抑制外周保幼激素 (JH) 反应,促进胰岛素信号传导。总之,我们确定了一个神经内分泌轴,由此 AdipoR 阳性神经元控制全身胰岛素反应。

更新日期:2021-09-24
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