The COVID-19 pandemic represents one of the greatest challenges in modern medicine. The disease is characterized by a variable clinical phenotype, ranging from asymptomatic carriage to severe and/or critical disease, which bears poor prognosis and outcome because of the development of severe acute respiratory distress syndrome (SARS) requiring ICU hospitalization, multi-organ failure and death. Therefore, the determination of risk factors predisposing to disease phenotype is of outmost importance. The aim of our study was to evaluate which predisposing factors, including MBL2 genotyping, affected clinical phenotype in 264 COVID-19 patients. We demonstrated that older age along with underlying comorbidities, primarily obesity, chronic inflammatory disorders and diabetes mellitus, represent the most important risk factors related to hospitalization, the development of pneumonia and SARS. Moreover, we found that the presence of the MBL deficiency-causing B allele (rs1800450) was significantly associated with almost 2-fold increased risk for developing pneumonia and requiring hospitalization, suggesting its usage as a molecular predictor of severe disease in SARS-CoV-2 infected individuals.

COVID-19 大流行是现代医学面临的最大挑战之一。该疾病的特点是临床表型多样，从无症状携带到严重和/或危重疾病，由于严重急性呼吸窘迫综合征 (SARS) 的发展需要 ICU 住院、多器官衰竭和死亡。因此，确定易患疾病表型的危险因素是最重要的。我们研究的目的是评估哪些诱发因素，包括MBL2基因分型，影响 264 名 COVID-19 患者的临床表型。我们证明，年龄较大以及潜在的合并症，主要是肥胖、慢性炎症性疾病和糖尿病，是与住院、肺炎和 SARS 的发展相关的最重要的风险因素。此外，我们发现导致 MBL 缺陷的 B 等位基因 (rs1800450) 的存在与患肺炎和需要住院治疗的风险增加近 2 倍显着相关，这表明它可作为 SARS-CoV 中严重疾病的分子预测因子。 2个感染者。