A clickable initiator, pentafluoro benzyl bromide, has been investigated for the cationic ring opening polymerization of poly(2-oxazolines). Additionally, the clickable alpha end group was then utilized in a para-fluoro-thiol click reaction to synthesise linear diblock, tetrablock, multiblock copolymers as well as star shaped poly(2-oxazoline)s using dithiol compounds as terminating agents. Thus, a one-pot approach combining the para-fluoro-thiol click reaction and direct termination of the poly(2-oxazoline) living chain end with 4,4-thiobisbenzenethiol has been performed to prepare multiblock copolymers of poly(2-ethyl-2-oxazoline) (PEtOx) and poly((2-ethyl-2-oxazoline)-b-(2-methyl-2-oxazoline) (PEtOx-mb-PMeOx). All obtained polymers were characterized by Size Exclusion Chromatography (SEC), ¹H Nuclear Magnetic Resonance (NMR) and Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-ToF) mass spectrometry. Last but not least, the self-assembly properties of prepared amphiphilic polymers were studied with DLS and TEM. Nanoparticles with a diameter ranging from 184 nm to 250 nm were observed in TEM for PEtOx-mb-PMeOx copolymers.

中文翻译：

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通过对氟硫醇点击反应一锅法合成两亲性多嵌段聚（2-恶唑啉）

一种可点击的引发剂，五氟苄基溴，已被研究用于聚（2-恶唑啉）的阳离子开环聚合。此外，可点击的 α 端基随后用于对氟硫醇点击反应，以使用二硫醇化合物作为终止剂合成线性二嵌段、四嵌段、多嵌段共聚物以及星形聚（2-恶唑啉）。因此，单罐方法合成段的聚（2-恶唑啉）活链端的氟硫醇点击反应并直接终止4,4-thiobisbenzenethiol已经执行，以制备聚（2-乙基-多嵌段共聚物2-恶唑啉）（PEtOx）和聚（（2-乙基-2-恶唑啉）- b -（2-甲基-2-恶唑啉）（PEtOx- mb-PMeOx)。所有获得的聚合物都通过尺寸排阻色谱 (SEC)、¹ H 核磁共振 (NMR) 和基质辅助激光解吸/电离飞行时间 (MALDI-ToF) 质谱进行表征。最后但并非最不重要的一点是，用 DLS 和 TEM 研究了制备的两亲聚合物的自组装性能。对于 PEtOx- mb -PMeOx 共聚物，在 TEM 中观察到直径范围为 184 nm 至 250 nm 的纳米颗粒。