Bicaudal-C protein is a highly conserved RNA binding protein, which contains K homology domains and sterile alpha motif domain. Genome-wide association study identified that Bicaudal-C protein was associated with depression. The expression of Bicaudal-C increased in depression patients, also increased expression of Bicaudal-C induces the behavior of depression. The decrease of synaptic plasticity plays a part in depression. Bicaudal-C protein reduces the synaptic plasticity of neurons via TrkB/mTOR/AMPA/pGluA1 pathways, Wnt pathway, or influencing some proteins related to synaptic plasticity. The decreased expression of Bicaudal-C plays an important role in the action of several antidepressants, such as ketamine, biperiden, and scopolamine. Therefore, Bicaudal-C protein may be a potential antidepressant target. Clarifying the relationship between Bicaudal-C protein and depression may help us to find new antidepressants. This review focuses on the research advances of the relationship between Bicaudal-C protein and depression.

中文翻译：

---

Bicaudal-C 蛋白，一种潜在的抗抑郁靶点。

Bicaudal-C蛋白是一种高度保守的RNA结合蛋白，含有K同源结构域和无菌α基序结构域。全基因组关联研究发现 Bicaudal-C 蛋白与抑郁症相关。抑郁症患者中Bicaudal-C表达增加，同时Bcaudal-C表达增加诱发抑郁行为。突触可塑性的下降与抑郁症有关。Bicaudal-C蛋白通过TrkB/mTOR/AMPA/pGluA1通路、Wnt通路降低神经元突触可塑性，或影响一些与突触可塑性相关的蛋白。Bicaudal-C 表达的降低在多种抗抑郁药（如氯胺酮、比哌立登和东莨菪碱）的作用中发挥着重要作用。因此，Bicaudal-C蛋白可能是一个潜在的抗抑郁靶点。阐明 Bicaudal-C 蛋白与抑郁症之间的关系可能有助于我们寻找新的抗抑郁药物。本文重点综述Bcaudal-C蛋白与抑郁症关系的研究进展。