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Nonparametric Parameters of 24-Hour Rest–Activity Rhythms and Long-Term Cognitive Decline and Incident Cognitive Impairment in Older Men
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 5.1 ) Pub Date : 2021-09-24 , DOI: 10.1093/gerona/glab275 Qian Xiao 1 , Joshua N Sampson 2 , Andrea Z LaCroix 3 , Aladdin H Shadyab 3 , Jamie M Zeitzer 4, 5 , Sonia Ancoli-Israel 6 , Kristin Yaffe 7 , Katie Stone 8 ,
中文翻译:
老年男性 24 小时休息-活动节律和长期认知衰退和偶发性认知障碍的非参数参数
更新日期:2021-09-24
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences ( IF 5.1 ) Pub Date : 2021-09-24 , DOI: 10.1093/gerona/glab275 Qian Xiao 1 , Joshua N Sampson 2 , Andrea Z LaCroix 3 , Aladdin H Shadyab 3 , Jamie M Zeitzer 4, 5 , Sonia Ancoli-Israel 6 , Kristin Yaffe 7 , Katie Stone 8 ,
Affiliation
Abstract
Altered 24-hour rest–activity rhythms may be associated with cognitive impairment in older adults, but evidence from prospective studies is limited. Nonparametric methods were used to assess actigraphy-based activity patterns in 2 496 older men. Incident cognitive impairment was assessed 4 times over 12 years using the Modified Mini-Mental State Examination (3MS) and Trails B tests, self-reported medication use, and clinical diagnosis. The highest quartile (vs the lowest) of intradaily variability and the lowest quartiles (vs the highest) of interdaily stability and relative amplitude were associated with incident cognitive impairment (hazard ratio [95% confidence interval]: 1.82 [1.31–2.53], 1.36 [0.99–1.86], and 1.85 [1.33–2.56], respectively). A larger increase in intradaily variability over 7.5 years was associated with a greater subsequent decline in 3MS scores but not in Trails B performance. In conclusion, less stable and more variable rest–activity rhythms may represent early biomarkers of cognitive impairment in older men.
中文翻译:
老年男性 24 小时休息-活动节律和长期认知衰退和偶发性认知障碍的非参数参数
摘要
24 小时休息-活动节律的改变可能与老年人的认知障碍有关,但来自前瞻性研究的证据有限。非参数方法用于评估 2 496 名老年男性的基于活动记录的活动模式。事件认知障碍在 12 年内使用改良的简易精神状态检查 (3MS) 和 Trails B 测试、自我报告的药物使用情况和临床诊断进行了 4 次评估。日内变异性的最高四分位数(相对于最低)和日间稳定性和相对幅度的最低四分位数(相对于最高四分位数)与事件认知障碍相关(风险比 [95% 置信区间]:1.82 [1.31–2.53],1.36 [0.99–1.86] 和 1.85 [1.33–2.56],分别)。日内变异性增加超过 7。5 年与随后 3MS 分数的更大下降有关,但与 Trails B 的表现无关。总之,不太稳定和更多变化的休息活动节律可能代表老年男性认知障碍的早期生物标志物。