Inspired by the tactic organisms in Nature that can self-direct their movement following environmental stimulus gradient, we proposed a DNase functionalized Janus nanoparticle (JNP) nanomotor system for the first time, which can be powered by ultralow nM to μM levels of DNA. The system exhibited interesting chemotactic behavior toward a DNA richer area, which is physiologically related with many diseases including tumors. In the presence of the subtle DNA gradient generated by apoptotic tumor cells, the cargo loaded nanomotors were able to sense the DNA signal released by the cells and demonstrate directional motion toward tumor cells. For our system, the subtle DNA gradient by a small amount (10 μL) of tumor cells is sufficient to induce the chemotaxis behavior of self-navigating and self-targeting ability of our nanomotor system, which promises to shed new light for tumor diagnosis and therapy.

中文翻译：

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凋亡肿瘤 DNA 激活的纳米马达趋化性

受到自然界中可以在环境刺激梯度下自我引导运动的战术生物的启发，我们首次提出了一种 DNase 功能化的 Janus 纳米粒子 (JNP) 纳米马达系统，该系统可以由超低 nM 到 μM 水平的 DNA 提供动力。该系统对富含 DNA 的区域表现出有趣的趋化行为，该区域与包括肿瘤在内的许多疾病在生理上有关。在凋亡肿瘤细胞产生的细微 DNA 梯度存在的情况下，装载货物的纳米马达能够感知细胞释放的 DNA 信号，并显示出朝向肿瘤细胞的定向运动。对于我们的系统，少量（10 μL）肿瘤细胞的细微DNA梯度足以诱导我们纳米马达系统的自导航和自靶向能力的趋化行为，