Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. However, increasing experimental and epidemiological research suggests that prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders. Here we summarize this evidence and call for precautionary action through a focused research effort and by increasing awareness among health professionals and pregnant women. APAP is an important medication and alternatives for treatment of high fever and severe pain are limited. We recommend that pregnant women should be cautioned at the beginning of pregnancy to: forego APAP unless its use is medically indicated; consult with a physician or pharmacist if they are uncertain whether use is indicated and before using on a long-term basis; and minimize exposure by using the lowest effective dose for the shortest possible time. We suggest specific actions to implement these recommendations. This Consensus Statement reflects our concerns and is currently supported by 91 scientists, clinicians and public health professionals from across the globe.

对乙酰氨基酚 ( N-乙酰- p-氨基苯酚 (APAP)，也称为对乙酰氨基酚）是 600 多种药物中的活性成分，用于缓解轻度至中度疼痛和退烧。APAP 被孕妇广泛使用，因为包括 FDA 和 EMA 在内的政府机构长期以来一直认为 APAP 在按照指示使用时适合在怀孕期间使用。然而，越来越多的实验和流行病学研究表明，产前暴露于 APAP 可能会改变胎儿发育，这可能会增加某些神经发育、生殖和泌尿生殖系统疾病的风险。在这里，我们总结了这些证据，并呼吁通过集中研究工作和提高卫生专业人员和孕妇的认识采取预防措施。APAP 是一种重要的药物，用于治疗高烧和剧烈疼痛的替代品是有限的。我们建议孕妇在怀孕初期应注意： 放弃 APAP，除非有医学指征；如果不确定是否需要使用，请在长期使用前咨询医生或药剂师；并通过在尽可能短的时间内使用最低有效剂量来最大限度地减少暴露。我们建议采取具体行动来实施这些建议。该共识声明反映了我们的担忧，目前得到全球 91 名科学家、临床医生和公共卫生专业人员的支持。并通过在尽可能短的时间内使用最低有效剂量来最大限度地减少暴露。我们建议采取具体行动来实施这些建议。该共识声明反映了我们的担忧，目前得到全球 91 名科学家、临床医生和公共卫生专业人员的支持。并通过在尽可能短的时间内使用最低有效剂量来最大限度地减少暴露。我们建议采取具体行动来实施这些建议。该共识声明反映了我们的担忧，目前得到全球 91 名科学家、临床医生和公共卫生专业人员的支持。