The unexplored role of sedentary time and physical activity in glucose and lipid metabolism-related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial,BJOG: An International Journal of Obstetrics & Gynaecology

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The unexplored role of sedentary time and physical activity in glucose and lipid metabolism-related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial
BJOG: An International Journal of Obstetrics & Gynaecology ( IF 5.8 ) Pub Date : 2021-09-24 , DOI: 10.1111/1471-0528.16945
P Acosta-Manzano _{1,

2} , B Leopold-Posch ₃ , D Simmons ₄ , R Devlieger ₅ , S Galjaard _{5,

6} , R Corcoy ₇ , J M Adelantado ₈ , F Dunne ₉ , J Harreiter ₁₀ , A Kautzky-Willer ₁₀ , P Damm ₁₁ , E R Mathiesen ₁₁ , D M Jensen _{12,

13,

14} , L L Andersen _{13,

14} , M Tanvig _{13,

14} , A Lapolla ₁₅ , M G Dalfra ₁₅ , A Bertolotto ₁₆ , E Wender-Ozegowska ₁₇ , A Zawiejska ₁₈ , D J Hill ₁₉ , F J Snoek ₂₀ , Jgm Jelsma ₂₁ , G Desoye ₃ , Mnm van Poppel ₂₂

Affiliation

PA-HELP 'Physical Activity for Health Promotion, CTS-1018' Research Group, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Department of Physical Education and Sports, Faculty of Sports Science, University of Granada, Granada, Spain.
Department of Obstetrics and Gynaecology, Medical University Graz, Graz, Austria.
Western Sydney University, Campbelltown, New South Wales, Australia.
Department of Development and Regeneration: Pregnancy, Fetus and Neonate, Gynaecology and Obstetrics, KU Leuven, University Hospitals Leuven, Leuven, Belgium.
Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
CIBER Bioengineering, Biomaterials and Nanomedicine, Instituto de Salud Carlos III, Zaragoza, Spain.
Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Galway Diabetes Research Centre (GDRC) and National University of Ireland, Galway, Ireland.
Gender Medicine Unit, Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Departments of Endocrinology and Obstetrics, Rigshospitalet and Department of Clinical Medicine, Centre for Pregnant Women with Diabetes, University of Copenhagen, Copenhagen, Denmark.
Steno Diabetes Centre Odense, Odense University Hospital, Odense, Denmark.
Department of Gynaecology and Obstetrics, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, Faculty of Health Science, University of Southern Denmark, Odense, Denmark.
Department of Medical and Surgical Sciences, Università degli Studi di Padova, Padua, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Department of Reproduction, Poznan University of Medical Sciences, Poznan, Poland.
Chair of Medical Education, Department of Medical Simulation, Poznan University of Medical Sciences, Poznan, Poland.
Lawson Health Research Institute, London, Ontario, Canada.
Department of Medical Psychology, Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, VU University, Amsterdam, the Netherlands.
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Institute of Human Movement Science, Sport and Health, University of Graz, Graz, Austria.

We aimed to explore: (i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with the placental expression of genes related to glucose and lipid metabolism in pregnant women who are obese; (ii) maternal metabolic factors mediating changes in these placental transcripts; and (iii) cord blood markers related to the mRNAs mediating neonatal adiposity.

中文翻译：

久坐时间和体力活动在肥胖孕妇糖脂代谢相关胎盘 mRNA 中的未探索作用：DALI 生活方式随机对照试验

我们旨在探讨：（i）妊娠期久坐时间（ST）和体力活动（PA）与肥胖孕妇糖脂代谢相关基因胎盘表达的关系；(ii) 介导这些胎盘转录物变化的母体代谢因素；(iii) 与介导新生儿肥胖的 mRNA 相关的脐带血标志物。

更新日期：2021-09-24

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