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Flavonoids with Potential Anti-Amyloidogenic Effects as Therapeutic Drugs for Treating Alzheimer’s Disease
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-23 , DOI: 10.3233/jad-210735
Qixin Wang 1 , Xiaofang Dong 1 , Ran Zhang 1 , Changqi Zhao 1
Affiliation  

Alzheimer’s disease (AD) is a central neurodegenerative disease generally among the elderly; it accounts for approximately 50–75%of total cases of dementia patients and poses a serious threat to physical and mental health. Currently available treatments for AD mainly relieves its symptoms, and effective therapy is urgently needed. Deposition of amyloid-β protein in the brain is an early and invariant neuropathological feature of AD. Currently the main efforts in developing anti-AD drugs focus on anti-amyloidogenic therapeutics that prevent amyloid-β production or aggregation and decrease the occurrence of neurotoxic events. The results of an increasing number of studies suggest that natural extracts and phytochemicals have a positive impact on brain aging. Flavonoids belong to the broad group of polyphenols and recent data indicate a favorable effect of flavonoids on brain aging. In this review, we collect relevant discoveries from 1999 to 2021, discuss 75 flavonoids that effectively influence AD pathogenesis, and summarize their functional mechanisms in detail. The data we have reviewed show that, these flavonoids belong to various subclasses, including flavone, flavanone, biflavone, etc. Our results provide a reference for further study of the effects of flavonoids on AD and the progress of anti-AD therapy.

中文翻译:

具有潜在抗淀粉样蛋白生成作用的黄酮类化合物作为治疗阿尔茨海默病的治疗药物

阿尔茨海默病 (AD) 是一种常见于老年人的中枢神经退行性疾病;它约占痴呆症患者总数的50-75%,对身心健康构成严重威胁。目前AD的治疗主要是缓解症状,迫切需要有效的治疗方法。β-淀粉样蛋白在脑中的沉积是 AD 的早期且不变的神经病理学特征。目前,开发抗 AD 药物的主要努力集中在抗淀粉样蛋白生成疗法上,该疗法可防止淀粉样蛋白-β 的产生或聚集并减少神经毒性事件的发生。越来越多的研究结果表明,天然提取物和植物化学物质对大脑衰老有积极影响。黄酮类化合物属于广泛的多酚类化合物,最近的数据表明黄酮类化合物对大脑衰老有良好的作用。在这篇综述中,我们收集了 1999 年至 2021 年的相关发现,讨论了 75 种有效影响 AD 发病机制的黄酮类化合物,并详细总结了它们的作用机制。我们查阅的资料表明,这些黄酮类化合物属于多个亚类,包括黄酮、黄烷酮、双黄酮等。我们的研究结果为进一步研究黄酮类化合物对AD的作用和抗AD治疗的进展提供了参考。
更新日期:2021-09-24
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