The present paper compared vitamin D levels in adult patients with obsessive-compulsive disorder (OCD) and explored possible correlations with patients’ characteristics.

Fifty outpatients with OCD, according to DSM-5 criteria, were included and assessed with the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Hamilton Rating Scale for Depression (HRDS).

All the patients except one showed lower vitamin D levels than normative values (>30 nm/L). Vitamin D values of the whole sample were negatively correlated with Y-BOCS total, compulsion subscale, and some items’ scores, specifically “interference from obsessions,” “distress associated with obsessions,” and “time spent on compulsions”. The same relationships were detected in men, while women showed negative correlations between vitamin D levels and Y-BOCS compulsion subscale and “resistance to compulsions,” “degree of control of compulsions,” “insight” item scores.

Our findings would indicate that vitamin D might be involved in the pathophysiology of OCD, and that it is possibly related to the severity of the disorder and to typical symptoms, with some sex-related peculiarities. Further studies are necessary to support or not our findings and to ascertain the effectiveness of vitamin D supplementation in patients with OCD.

本文比较了患有强迫症 (OCD) 的成年患者的维生素 D 水平，并探讨了与患者特征之间可能的相关性。

根据DSM-5标准，纳入了50名强迫症门诊患者，并使用耶鲁-布朗强迫量表（Y-BOCS）和汉密尔顿抑郁量表（HRDS）进行评估。

除一名患者外，所有患者的维生素 D 水平均低于正常值 (>30 nm/L)。整个样本的维生素D值与Y-BOCS总量、强迫分量表和某些项目的得分呈负相关，特别是“强迫观念的干扰”、“与强迫观念相关的痛苦”和“强迫行为所花费的时间”。在男性中也发现了同样的关系，而女性中维生素 D 水平与 Y-BOCS 强迫量表以及“对强迫的抵抗力”、“强迫的控制程度”和“洞察力”项目得分之间呈负相关。

我们的研究结果表明，维生素 D 可能与强迫症的病理生理学有关，并且可能与该疾病的严重程度和典型症状有关，并具有一些与性别相关的特征。需要进一步的研究来支持或不支持我们的研究结果，并确定补充维生素 D 对强迫症患者的有效性。