A member of cathepsin enzymes called Cathepsin B is a cysteine-protease enzyme that plays significant role in metalloproteinase regulation. Cathepsin B stands out amidst other members of cathepsin because of its role in both normal body physiology and pathophysiology. Being an antiapoptotic and a pro-apoptotic agent, Cathepsin B has been reported to have deleterious effects, especially when its expression, activities, and distribution are outrageous. The over-expression of cathepsin B is traceable to dysregulation of one or more regulated steps involved in its synthesis. Consequently, the over-expression of cathepsin B contributes to the pathogenesis of different types of cancers - a global menace. Interestingly, the synthesis of this enzyme has been reported to be inhibited by several metal compounds, thus, curbing its involvement in carcinogenesis. In this review, the synthesis, structure, localization, and roles of cathepsin B in carcinogenesis were explored. Likewise, we also discussed the capacity of metallic compounds to inhibit this enzyme. Metals such as gold, ruthenium, palladium, Iridium, and Tellurium demonstrated remarkable activity toward cathepsin B of different modes. A relationship between cytotoxicity and inhibition constants was observed.

称为组织蛋白酶 B 的组织蛋白酶的成员是一种半胱氨酸蛋白酶，在金属蛋白酶调节中起重要作用。组织蛋白酶 B 在组织蛋白酶的其他成员中脱颖而出，因为它在正常的身体生理学和病理生理学中都发挥作用。作为一种抗凋亡剂和促凋亡剂，据报道组织蛋白酶 B 具有有害作用，尤其是当其表达、活性和分布异常时。组织蛋白酶 B 的过度表达可追溯到其合成中涉及的一个或多个调节步骤的失调。因此，组织蛋白酶 B 的过度表达有助于不同类型癌症的发病机制——这是一种全球性威胁。有趣的是，据报道这种酶的合成受到几种金属化合物的抑制，因此，遏制其参与致癌作用。在这篇综述中，探讨了组织蛋白酶 B 在致癌作用中的合成、结构、定位和作用。同样，我们还讨论了金属化合物抑制这种酶的能力。金、钌、钯、铱和碲等金属对不同模式的组织蛋白酶 B 表现出显着的活性。观察到细胞毒性和抑制常数之间的关系。