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Stingless Bee Propolis: New Insights for Anticancer Drugs
Oxidative Medicine and Cellular Longevity ( IF 7.310 ) Pub Date : 2021-09-23 , DOI: 10.1155/2021/2169017
Jaqueline Ferreira Campos 1 , Helder Freitas Dos Santos 1 , Thaliny Bonamigo 1 , Nelson Luís de Campos Domingues 2 , Kely de Picoli Souza 1 , Edson Lucas Dos Santos 1
Affiliation  

Natural products are important sources of biomolecules possessing antitumor activity and can be used as anticancer drug prototypes. The rich biodiversity of tropical and subtropical regions of the world provides considerable bioprospecting potential, including the potential of propolis produced by stingless bee species. Investigations of the potential of these products are extremely important, not only for providing a scientific basis for their use as adjuvants for existing drug therapies but also as a source of new and potent anticancer drugs. In this context, this article organizes the main studies describing the anticancer potential of propolis from different species of stingless bees with an emphasis on the chemical compounds, mechanisms of action, and cell death profiles. These mechanisms include apoptotic events; modulation of BAX, BAD, BCL2-L1 (BCL-2 like 1), and BCL-2; depolarization of the mitochondrial membrane; increased caspase-3 activity; poly (ADP-ribose) polymerase (PARP) cleavage; and cell death induction by necroptosis via receptor interacting protein kinase 1 (RIPK1) activation. Additionally, the correlation between compounds with antioxidant and anti-inflammatory potential is demonstrated that help in the prevention of cancer development. In summary, we highlight the important antitumor potential of propolis from stingless bees, but further preclinical and clinical trials are needed to explore the selectivity, efficacy, and safety of propolis.

中文翻译:

无刺蜂胶:抗癌药物的新见解

天然产物是具有抗肿瘤活性的生物分子的重要来源,可作为抗癌药物的原型。世界热带和亚热带地区丰富的生物多样性提供了相当大的生物勘探潜力,包括无刺蜂种生产的蜂胶的潜力。研究这些产品的潜力非常重要,不仅可以为它们用作现有药物疗法的佐剂提供科学依据,还可以作为新的有效抗癌药物的来源。在此背景下,本文组织了描述不同种类无刺蜜蜂蜂胶抗癌潜力的主要研究,重点介绍了化学成分、作用机制和细胞死亡概况。这些机制包括凋亡事件;BAX、BAD、BCL2-L1(BCL-2 类似 1)和 BCL-2;线粒体膜去极化;增加 caspase-3 活性;聚 (ADP-核糖) 聚合酶 (PARP) 切割;和通过受体相互作用蛋白激酶 1 (RIPK1) 激活通过坏死性凋亡诱导细胞死亡。此外,具有抗氧化和抗炎潜力的化合物之间的相关性被证明有助于预防癌症的发展。总之,我们强调了无刺蜜蜂蜂胶的重要抗肿瘤潜力,但需要进一步的临床前和临床试验来探索蜂胶的选择性、有效性和安全性。和通过受体相互作用蛋白激酶 1 (RIPK1) 激活通过坏死性凋亡诱导细胞死亡。此外,具有抗氧化和抗炎潜力的化合物之间的相关性被证明有助于预防癌症的发展。总之,我们强调了无刺蜜蜂蜂胶的重要抗肿瘤潜力,但需要进一步的临床前和临床试验来探索蜂胶的选择性、有效性和安全性。和通过受体相互作用蛋白激酶 1 (RIPK1) 激活通过坏死性凋亡诱导细胞死亡。此外,具有抗氧化和抗炎潜力的化合物之间的相关性被证明有助于预防癌症的发展。总之,我们强调了无刺蜜蜂蜂胶的重要抗肿瘤潜力,但需要进一步的临床前和临床试验来探索蜂胶的选择性、有效性和安全性。
更新日期:2021-09-23
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