Purpose

Ointments and creams used in burn treatments have limitations that compromise their effectiveness since they dry on the skin, their removal/replacement is traumatic and the half-life of the active ingredient is short requiring more applications during treatment. In this context, the objective was to develop a biofilm with potential biotherapeutics for differential treatment of burns.

Methods

The methodology involved prospecting, method development, and synthesis of biofilm with biotherapeutic potential, its characterization and also assessment of its pharmacological and microbiological properties.

Results

The resulting biofilm with potential biotherapeutic showed a water solubility of 37.82%, moisture vapour permeability of 1.887 g (10 cm² 24 h)⁻¹, water vapour permeability of 0.743 g (10 cm² 24 h)⁻¹, silver amount of 9608.377 mg L⁻¹, low silver release rate and microbiological inhibition capacity.

Conclusion

This new biofilm with potential biotherapeutic shows better absorption/release of the active ingredient, longer half-life, increased inhibition of microorganism proliferation, greater moisture-holding capacity and better hydration of the skin. These features facilitate dressing change without traumatizing the injured tissue. In short, the new biofilm should provide efficient and less traumatic treatment of burns.

中文翻译：

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磺胺嘧啶银丝胶生物膜治疗烧伤

目的

烧伤治疗中使用的软膏和乳膏具有局限性，会影响其有效性，因为它们会在皮肤上干燥，它们的移除/更换是创伤性的，并且活性成分的半衰期很短，需要在治疗过程中多次使用。在这种情况下，目标是开发一种具有潜在生物疗法的生物膜，用于烧伤的差异化治疗。

方法

该方法涉及具有生物治疗潜力的生物膜的勘探、方法开发和合成、其表征以及对其药理学和微生物学特性的评估。

结果

所得具有潜在生物治疗性的生物膜显示出37.82%的水溶性、1.887 g (10 cm ² 24 h) ^-1、0.743 g (10 cm ² 24 h) ^-1水蒸汽渗透率、9608.377银含量mg L ^-1，低银释放率和微生物抑制能力。

结论

这种具有潜在生物治疗作用的新型生物膜显示出更好的活性成分吸收/释放、更长的半衰期、增强对微生物增殖的抑制、更大的保湿能力和更好的皮肤水合作用。这些特点有助于更换敷料，而不会伤害受伤的组织。简而言之，新的生物膜应该为烧伤提供有效且创伤更小的治疗。