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A high sensitivity electrochemical sensor based on a dual-template molecularly imprinted polymer for simultaneous determination of clenbuterol hydrochloride and ractopamine
Analyst ( IF 4.2 ) Pub Date : 2021-08-31 , DOI: 10.1039/d1an01413g
Xiang Li 1 , Yangguang Li 1 , Pai Yu 1 , Yanbin Tong 1 , Bang-Ce Ye 1, 2
Affiliation  

A nitrogen-doped Fe-MOF shows a high specific surface area and excellent electrical conductivity after high temperature carbonization. A novel electrochemical sensor based on a N@Fe-MOF@C loaded dual-template molecularly imprinted polymer (DTMIP) modified glassy carbon electrode (GCE) was proposed for the rapid and ultra-sensitive simultaneous detection of clenbuterol hydrochloride (CLB) and ractopamine (RAC). N@Fe-MOF@C combined with a MIP significantly enhanced the electrical signal. Cyclic voltammetry (CV) was used to detect CLB and RAC. The electrochemical polymerization was conducted with O-phenylenediamine as the functional monomer and CLB and RAC as template molecules. The factors affecting the sensor response were optimized. Under the optimal experimental conditions, the CV current response showed a linear range of 10−12–8 × 10−9 M for both CLB and RAC, and the detection limit (LOD) for both CLB and RAC was 3.03 × 10−13 M (S/N = 3). This electrochemical sensing system has high sensitivity, selectivity, excellent reproducibility, repeatability and stability. The recoveries of the actual samples (97.4%–101.2%) and reasonable relative standard deviations (RSDs) (1.06%–3.17%) indicate the practicability of the sensor system. The system has high application value in the rapid detection of CLB and RAC in clenbuterol hydrochloride tablets, human urine and raw pork.

中文翻译:

基于双模板分子印迹聚合物的高灵敏度电化学传感器,用于同时测定盐酸克伦特罗和莱克多巴胺

氮掺杂的 Fe-MOF 在高温碳化后显示出高比表面积和优异的导电性。提出了一种基于 N@Fe-MOF@C 负载双模板分子印迹聚合物 (DTMIP) 修饰的玻碳电极 (GCE) 的新型电化学传感器,用于快速、超灵敏地同时检测盐酸克伦特罗 (CLB) 和莱克多巴胺(RAC)。N@Fe-MOF@C 与 MIP 结合显着增强了电信号。循环伏安法 (CV) 用于检测 CLB 和 RAC。电化学聚合采用O-苯二胺作为功能单体,CLB和RAC作为模板分子。对影响传感器响应的因素进行了优化。在最佳实验条件下,CLB 和 RAC的 CV 电流响应线性范围为 10 -12 –8 × 10 -9 M,CLB 和 RAC 的检测限 (LOD) 均为 3.03 × 10 -13M(信噪比 = 3)。这种电化学传感系统具有高灵敏度、选择性、优良的重现性、重复性和稳定性。实际样品的回收率 (97.4%–101.2%) 和合理的相对标准偏差 (RSD) (1.06%–3.17%) 表明传感器系统的实用性。该系统在盐酸克伦特罗片、人尿、生猪肉中CLB和RAC的快速检测中具有较高的应用价值。
更新日期:2021-09-23
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