The Immunology & Cell Biology Publication of the Year Awards have been established for outstanding studies submitted by first authors who are financial members of the Australian & New Zealand Society for Immunology Inc. in the year of the article's publication. Articles vying for these awards can come from any of the journal categories including Original Articles, Outstanding Observations, Perspectives or Short Communications. The ASI President together with members of the ASI Executive and the Immunology & Cell Biology Editorial Team undertake rigorous review to identify the most outstanding original research articles based on scientific excellence. The winner of the Chris and Bhama Parish ICB Publication of the Year Award is awarded an AU$1000 scholarship provided by Wiley and the runner-up is awarded an AU$500 scholarship provided by Thermo Fisher Scientific.

The winning paper by Kapetanovic et al.¹ is an Original Article entitled “Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages” and was published in August 2020. This study by Kapetanovic et al. is an elegant and thoughtful investigation that lies at the interface of immunology and cell biology. Lipopolysaccharide (LPS) potently regulates macrophage metabolism and by consequence, mitochondrial functions. In this study, Kapetanovic et al. address the question of how LPS activation can lead to mitochondrial fission in macrophages and show that the Tlr4–MyD88–Drp1 pathway mediates the LPS-induced fission. Additionally, they discover that some but not all downstream LPS-associated inflammatory responses are dependent upon Drp1 and mitochondrial fission. This exciting study begins to dissect the molecular signals that activate and control microbial-associated mitochondrial changes in macrophages with the hope that understanding these signals may reveal new therapeutic targets to treat inflammatory diseases.

The Original Article by Patton et al.,² “Daptomycin-resistant Staphylococcus aureus clinical isolates are poorly sensed by dendritic cells,” published in January 2020, is the winner of the Thermo Fisher Scientific Publication Award for 2020. Patton et al. investigated an intriguing question, “Does antibiotic resistance in a microbe alter how the immune system responds to that microbe?” To address this novel question, Patton et al. evaluated how dendritic cells (DC) responded to clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) that were also daptomycin resistant or sensitive (DapR or DapS). They found that DC produced significantly lower levels of most cytokines in response to DapR than a matched DapS isolate. Interestingly, they determined that cDC1 were primarily responsible for the differential response and linked the reduced DC activation by DapR isolates to mutations in the S. aureus cls2 gene. While one of the strengths of this study lies in the paired DapS and DapR MRSA isolates for these analyses, by far the greatest strength of this study lies in asking the right questions and then developing new ways to answer them.

The award-winning papers by Drs Kapetanovic and Patton highlight the outstanding quality of the work published in Immunology & Cell Biology. My very best congratulations are extended to the awardees on their success. I also thank our sponsors, Wiley and Thermo Fisher Scientific, for their continued support of outstanding science and scientists and the journal. It is hoped that the outstanding quality of these awarded publications will also encourage others to consider Immunology & Cell Biology as a key journal for their cutting-edge research.

Ronan Kapetanovic joint recipient of the 2020 Chris and Bhama Parish ICB Publication of the Year Award.

Timothy Patton, recipient of the 2020 Thermo Fisher Scientific Publication Award.

Farhana Afroz, joint recipient of the 2020 Chris and Bhama Parish ICB Publication of the Year Award.

在免疫学，细胞生物学年度大奖的出版物已经建立了提交的第一作者是谁在文章的出版年份，澳大利亚和新西兰社会为免疫公司的财务成员出色的研究。争夺这些奖项的文章可以来自任何期刊类别，包括原创文章、杰出观察、观点或短通讯。ASI 主席与 ASI 执行官和免疫学与细胞生物学的成员一起编辑团队进行严格的审查，以基于科学卓越性来确定最杰出的原创研究文章。克里斯和巴马教区 ICB 年度出版物奖的获得者将获得 Wiley 提供的 1000 澳元奖学金，亚军获得赛默飞世尔科技提供的 500 澳元奖学金。

Kapetanovic等人的获奖论文。¹是一篇题为“脂多糖促进巨噬细胞中Drp1依赖性线粒体裂变和相关炎症反应”的原创文章，发表于2020年8月。Kapetanovic等人的这项研究。是一项优雅而深思熟虑的研究，位于免疫学和细胞生物学的交界处。脂多糖 (LPS) 有效地调节巨噬细胞代谢，从而调节线粒体功能。在这项研究中，Kapetanovic等人. 解决 LPS 激活如何导致巨噬细胞线粒体裂变的问题，并表明 Tlr4-MyD88-Drp1 通路介导 LPS 诱导的裂变。此外，他们发现部分而非全部下游 LPS 相关炎症反应依赖于 Drp1 和线粒体裂变。这项激动人心的研究开始剖析激活和控制巨噬细胞中微生物相关线粒体变化的分子信号，希望了解这些信号可以揭示治疗炎症性疾病的新治疗靶点。

通过巴顿原来的文章等，² “达托霉素耐药的金黄色葡萄球菌临床分离不善树突状细胞感觉到，”发表在2020年1月，是在赛默飞世尔科技出版奖的2020年巴顿获胜者等。调查了一个有趣的问题，“微生物的抗生素耐药性是否会改变免疫系统对该微生物的反应？” 为了解决这个新问题，巴顿等人。评估树突状细胞 (DC) 如何对耐甲氧西林金黄色葡萄球菌的临床分离株作出反应(MRSA) 也对达托霉素耐药或敏感（DapR 或 DapS）。他们发现 DC 响应 DapR 产生的大多数细胞因子水平明显低于匹配的 DapS 分离株。有趣的是，他们确定 cDC1 主要负责差异反应，并将 DapR 分离株减少的 DC 激活与S突变联系起来。 金黄色葡萄球菌 cls2基因。虽然这项研究的优势之一在于用于这些分析的配对 DapS 和 DapR MRSA 分离株，但到目前为止，这项研究的最大优势在于提出正确的问题，然后开发新的方法来回答这些问题。

Kapetanovic 博士和 Patton 博士的获奖论文突出了发表在Immunology & Cell Biology上的工作的卓越品质。我对获奖者的成功表示最诚挚的祝贺。我还要感谢我们的赞助商 Wiley 和 Thermo Fisher Scientific，感谢他们对杰出科学和科学家以及期刊的持续支持。希望这些获奖出版物的卓越品质也将鼓励其他人将免疫学与细胞生物学视为其前沿研究的关键期刊。

Ronan Kapetanovic 是 2020 年克里斯和巴马教区 ICB 年度出版物奖的联合获得者。

Timothy Patton，2020 年赛默飞世尔科学出版奖获得者。

Farhana Afroz，2020 年克里斯和巴马教区 ICB 年度出版物奖的联合获得者。