Background The clinical significance of the discrepancy between left ventricular hypertrophy (LVH) by echocardiography and ECG remains to be elucidated. Methods After excluding patients who presented with pacemaker placement, QRS duration ≥120 ms and cardiomyopathy and moderate to severe valvular disease, we retrospectively analysed 3212 patients who had undergone both scheduled transthoracic echocardiography (echo) and ECG in a hospital-based population. Cornell product >2440 mm · ms was defined as ECG-based LVH; left ventricular mass index >115 g/m2 for men and >95 g/m2 for women was defined as echo-based LVH. The study population was categorised into four groups: patients with both ECG-based and echo-based LVH (N=131, 4.1%), those with only echo-based LVH (N=156, 4.9%), those with only ECG-based LVH (N=409, 12.7%) and those with no LVH (N=2516, 78.3%). Results The cumulative 3-year incidences of a composite of all-cause death and major adverse cardiovascular events were 32.0%, 33.8%, 19.2% and 15.7%, respectively. After adjusting for confounders, the HRs relative to that in no LVH were 1.63 (95% CI 1.16 to 2.28), 1.68 (95% CI 1.23 to 2.30) and 1.09 (95% CI 0.85 to 1.41) in patients with both ECG-based and echo-based LVH, those with only echo-based LVH, and those with only ECG-based LVH, respectively. Conclusions Echo-based LVH without ECG-based LVH was associated with a significant risk of adverse clinical events, and the risk was comparable to that in patients with both echo-based and ECG-based LVH. Data are available upon reasonable request. All relevant data are within the manuscript. The raw data will be provided upon the reasonable request to the corresponding author.

中文翻译：

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超声心动图左心室肥厚与心电图肥厚之间的差异：临床特征和结果

背景超声心动图显示的左心室肥厚 (LVH) 与 ECG 之间差异的临床意义仍有待阐明。方法 在排除了放置起搏器、QRS 持续时间≥120 ms 和心肌病和中重度瓣膜疾病的患者后，我们回顾性分析了医院人群中 3212 例接受预定经胸超声心动图 (echo) 和 ECG 的患者。Cornell 积 >2440 mm·ms 定义为基于 ECG 的 LVH；男性左心室质量指数 >115 g/m2 和女性 >95 g/m2 被定义为基于回声的 LVH。研究人群分为四组：同时具有基于 ECG 和基于回声的 LVH 的患者（N=131，4.1%），仅具有基于回声的 LVH 的患者（N=156，4.9%），仅具有 ECG 的患者基于 LVH (N=409, 12. 7%) 和那些没有 LVH (N=2516, 78.3%)。结果 全因死亡和主要不良心血管事件复合的 3 年累积发生率分别为 32.0%、33.8%、19.2% 和 15.7%。调整混杂因素后，在两种基于 ECG 的患者中，相对于无 LVH 的 HR 分别为 1.63（95% CI 1.16 至 2.28）、1.68（95% CI 1.23 至 2.30）和 1.09（95% CI 0.85 至 1.41）和基于回声的 LVH、仅基于回声的 LVH 和仅基于心电图的 LVH。结论 基于回声的 LVH 没有基于 ECG 的 LVH 与显着的不良临床事件风险相关，并且该风险与基于回声和基于 ECG 的 LVH 患者的风险相当。可应合理要求提供数据。所有相关数据都在手稿中。