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Associations between DNA methylation and telomere length during early life: Insight from wild zebra finches (Taeniopygia guttata)
Molecular Ecology ( IF 4.9 ) Pub Date : 2021-09-22 , DOI: 10.1111/mec.16187
Elizabeth L Sheldon 1 , Riccardo Ton 1 , Winnie Boner 2 , Pat Monaghan 2 , Shirley Raveh 2 , Aaron W Schrey 3 , Simon C Griffith 1
Affiliation  

Telomere length and DNA methylation (DNAm) are two promising biomarkers of biological age. Environmental factors and life history traits are known to affect variation in both these biomarkers, especially during early life, yet surprisingly little is known about their reciprocal association, especially in natural populations. Here, we explore how variation in DNAm, growth rate, and early-life conditions are associated with telomere length changes during development. We tested these associations by collecting data from wild, nestling zebra finches in the Australian desert. We found that increases in the level of DNAm were negatively correlated with telomere length changes across early life. We also confirm previously documented effects of post hatch growth rate and clutch size on telomere length in a natural ecological context for a species that has been extensively studied in the laboratory. However, we did not detect any effect of ambient temperature during developmental on telomere length dynamics. We also found that the absolute telomere length of wild zebra finches, measured using the in-gel TRF method, was similar to that of captive birds. Our findings highlight exciting new opportunities to link and disentangle potential relationships between DNA based biomarkers of ageing, and of physiological reactions to environmental change.

中文翻译:

生命早期 DNA 甲基化与端粒长度之间的关联:来自野生斑胸草雀 (Taeniopygia guttata) 的见解

端粒长度和 DNA 甲基化 (DNAm) 是生物年龄的两个有前途的生物标志物。众所周知,环境因素和生活史特征会影响这两种生物标志物的变异,尤其是在生命早期,但令人惊讶的是,人们对它们的相互关联知之甚少,尤其是在自然人群中。在这里,我们探讨了 DNAm、生长速率和生命早期条件的变化如何与发育过程中的端粒长度变化相关联。我们通过收集澳大利亚沙漠中野生、雏鸟斑马雀的数据来测试这些关联。我们发现 DNAm 水平的增加与整个生命早期的端粒长度变化呈负相关。我们还证实了先前记录的孵化后增长率和离合器大小对自然生态环境中端粒长度的影响,该物种已在实验室进行了广泛研究。然而,我们没有检测到环境温度在发育过程中对端粒长度动态的任何影响。我们还发现,使用凝胶内 TRF 方法测量的野生斑胸草雀的绝对端粒长度与圈养鸟类的端粒长度相似。我们的研究结果突出了令人兴奋的新机会,可以联系和理清基于 DNA 的衰老生物标志物与对环境变化的生理反应之间的潜在关系。我们还发现,使用凝胶内 TRF 方法测量的野生斑胸草雀的绝对端粒长度与圈养鸟类的端粒长度相似。我们的研究结果突出了令人兴奋的新机会,可以联系和理清基于 DNA 的衰老生物标志物与对环境变化的生理反应之间的潜在关系。我们还发现,使用凝胶内 TRF 方法测量的野生斑胸草雀的绝对端粒长度与圈养鸟类的端粒长度相似。我们的研究结果突出了令人兴奋的新机会,可以联系和理清基于 DNA 的衰老生物标志物与对环境变化的生理反应之间的潜在关系。
更新日期:2021-09-22
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