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In Vivo Near-Infrared Imaging Using Ternary Selenide Semiconductor Nanoparticles with an Uncommon Crystal Structure
Small ( IF 13.3 ) Pub Date : 2021-09-23 , DOI: 10.1002/smll.202103505
Jingke Yao 1 , José Lifante 1, 2, 3 , Paloma Rodríguez-Sevilla 1 , María de la Fuente-Fernández 3 , Francisco Sanz-Rodríguez 1, 2, 4 , Dirk H Ortgies 1, 2 , Oscar Gomez Calderon 5 , Sonia Melle 5 , Erving Ximendes 1, 2 , Daniel Jaque 1, 2 , Riccardo Marin 1
Affiliation  

The implementation of in vivo fluorescence imaging as a reliable diagnostic imaging modality at the clinical level is still far from reality. Plenty of work remains ahead to provide medical practitioners with solid proof of the potential advantages of this imaging technique. To do so, one of the key objectives is to better the optical performance of dedicated contrast agents, thus improving the resolution and penetration depth achievable. This direction is followed here and the use of a novel AgInSe2 nanoparticle-based contrast agent (nanocapsule) is reported for fluorescence imaging. The use of an Ag2Se seeds-mediated synthesis method allows stabilizing an uncommon orthorhombic crystal structure, which endows the material with emission in the second biological window (1000–1400 nm), where deeper penetration in tissues is achieved. The nanocapsules, obtained via phospholipid-assisted encapsulation of the AgInSe2 nanoparticles, comply with the mandatory requisites for an imaging contrast agent—colloidal stability and negligible toxicity—and show superior brightness compared with widely used Ag2S nanoparticles. Imaging experiments point to the great potential of the novel AgInSe2-based nanocapsules for high-resolution, whole-body in vivo imaging. Their extended permanence time within blood vessels make them especially suitable for prolonged imaging of the cardiovascular system.

中文翻译:

使用具有罕见晶体结构的三元硒化物半导体纳米粒子进行体内近红外成像

将体内荧光成像作为一种可靠的诊断成像方式在临床水平上实施还远未实现。为了向医疗从业者提供这种成像技术潜在优势的有力证据,仍有大量工作要做。为此,关键目标之一是提高专用造影剂的光学性能,从而提高可实现的分辨率和穿透深度。此处遵循该方向,并报告了使用新型 AgInSe 2纳米颗粒造影剂(纳米胶囊)进行荧光成像。使用 Ag 2Se 种子介导的合成方法可以稳定一种不常见的正交晶体结构,这使材料能够在第二个生物窗口(1000-1400 nm)中发射,从而实现更深的组织渗透。通过磷脂辅助封装 AgInSe 2纳米颗粒获得的纳米胶囊符合成像造影剂的强制性要求——胶体稳定性和可忽略不计的毒性——并且与广泛使用的 Ag 2 S 纳米颗粒相比显示出优异的亮度。成像实验表明新型 AgInSe 2的巨大潜力基于纳米胶囊的高分辨率全身体内成像。它们在血管内的延长持久时间使它们特别适用于心血管系统的长时间成像。
更新日期:2021-10-21
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