The TPP-β-cyclodextrin/chitosan (TPP-β-CD/CS) nanoparticles loading with curcumin (Cur) and vitamin C (Vc) was prepared via controllable self-assembly. The cross-linking reaction between TPP-β-CD and CS, and co-encapsulation of Cur and Vc in TPP-β-CD/CS nanoparticles were confirmed by the fourier-transform infrared (FTIR), UV–Vis (UV), X-ray diffraction (XRD), atomic force microscope (AFM), and particle size analyzer. The results of stability and antioxidant activity indicated that co-encapsulation not only enhanced the chemical stability of Cur and Vc, but also improved antioxidant properties compared with the active ingredients used alone. Release kinetic fitted by Ritger–Peppas model revealed that the release of dual active ingredients were mainly dominated by Fickian diffusion in pH 1.2, while followed non-Fickian or anomalous diffusion in pH 7.4. Furthermore, the two-dimensional UV correlation spectroscopy (2D-UV-COS) confirmed that the release rate of Cur was faster than that of Vc during co-delivery, which helps to precisely elucidate the synergistic nutraceuticals effect of each active ingredient.

通过可控自组装制备了负载姜黄素 (Cur) 和维生素 C (Vc) 的 TPP-β-环糊精/壳聚糖 (TPP-β-CD/CS) 纳米颗粒。TPP-β-CD 和 CS 之间的交联反应以及 Cur 和 Vc 在 TPP-β-CD/CS 纳米颗粒中的共包封通过傅里叶变换红外 (FTIR)、UV-Vis (UV)、 X 射线衍射 (XRD)、原子力显微镜 (AFM) 和粒度分析仪。稳定性和抗氧化活性的结果表明，与单独使用的活性成分相比，共包封不仅增强了 Cur 和 Vc 的化学稳定性，而且提高了抗氧化性能。Ritger-Peppas 模型拟合的释放动力学表明，在 pH 1.2 时，双重活性成分的释放主要受 Fickian 扩散支配，而在 pH 7.4 中遵循非 Fickian 或异常扩散。此外，二维紫外相关光谱（2D-UV-COS）证实，在共递送过程中，Cur 的释放速度比 Vc 快，这有助于精确阐明每种活性成分的协同保健作用。