The fluorine atom and fluorinated substituents are currently key motifs in pharmaceutical and agrochemical active ingredients, since they often beneficially modulate the physico-chemical and biological properties of the latter when installed in place of a hydrogen substituent. Among such fluorinated moieties, –OCHF₂ is emerging as an interesting group, which is notably capable of forming a hydrogen bond. These appealing properties have led to a growing need for introduction methods of this group. In this review we summarize all current methods allowing access to the –OCHF₂ moiety. We will hence discuss procedures applicable to either aromatic or aliphatic substrates, and based on different disconnections, including difluoromethylation of alcohols, or radical addition onto arenes.

氟原子和氟化取代基目前是药物和农业化学活性成分中的关键基序，因为当它们代替氢取代基安装时，它们通常可以有益地调节后者的物理化学和生物特性。在这些氟化部分中，–OCHF ₂正在成为一个有趣的基团，它特别能够形成氢键。这些吸引人的特性导致对这一群体的引入方法的需求不断增长。在这篇综述中，我们总结了所有当前允许访问 –OCHF ₂部分的方法。因此，我们将讨论适用于芳香族或脂肪族底物的程序，并基于不同的断开连接，包括醇的二氟甲基化或芳烃上的自由基加成。