Aortic diseases are the primary public health concern. As asymptomatic diseases, abdominal aortic aneurysm (AAA) and atherosclerosis are associated with high morbidity and mortality. The inflammatory process constitutes an essential part of a pathogenic cascade of aortic diseases, including atherosclerosis and aortic aneurysms. Inflammation on various vascular beds, including endothelium, smooth muscle cell proliferation and migration, and inflammatory cell infiltration (monocytes, macrophages, neutrophils, etc.), play critical roles in the initiation and progression of aortic diseases. The tryptophan (Trp) metabolism or kynurenine pathway (KP) is the primary way of degrading Trp in most mammalian cells, disturbed by cytokines under various stress. KP generates several bioactive catabolites, such as kynurenine (Kyn), kynurenic acid (KA), 3-hydroxykynurenine (3-HK), etc. Depends on the cell types, these metabolites can elicit both hyper- and anti-inflammatory effects. Accumulating evidence obtained from various animal disease models indicates that KP contributes to the inflammatory process during the development of vascular disease, notably atherosclerosis and aneurysm development. This review outlines current insights into how perturbed Trp metabolism instigates aortic inflammation and aortic disease phenotypes. We also briefly highlight how targeting Trp metabolic pathways should be considered for treating aortic diseases.

主动脉疾病是主要的公共卫生问题。作为无症状疾病，腹主动脉瘤 (AAA) 和动脉粥样硬化与高发病率和死亡率相关。炎症过程构成了主动脉疾病（包括动脉粥样硬化和主动脉瘤）的致病级联反应的重要组成部分。各种血管床上的炎症，包括内皮、平滑肌细胞增殖和迁移以及炎症细胞浸润（单核细胞、巨噬细胞、中性粒细胞等），在主动脉疾病的发生和发展中起关键作用。色氨酸 (Trp) 代谢或犬尿氨酸途径 (KP) 是大多数哺乳动物细胞中降解色氨酸的主要方式，在各种压力下受到细胞因子的干扰。KP 产生多种生物活性分解代谢物，如犬尿氨酸 (Kyn)、犬尿氨酸 (KA)、3-羟基犬尿氨酸 (3-HK) 等。取决于细胞类型，这些代谢物可以引起过度炎症和抗炎作用。从各种动物疾病模型中获得的越来越多的证据表明，KP 有助于血管疾病发展过程中的炎症过程，特别是动脉粥样硬化和动脉瘤的发展。这篇综述概述了当前对 Trp 代谢紊乱如何引发主动脉炎症和主动脉疾病表型的见解。我们还简要强调了如何考虑针对 Trp 代谢途径治疗主动脉疾病。从各种动物疾病模型中获得的越来越多的证据表明，KP 有助于血管疾病发展过程中的炎症过程，特别是动脉粥样硬化和动脉瘤的发展。这篇综述概述了当前对 Trp 代谢紊乱如何引发主动脉炎症和主动脉疾病表型的见解。我们还简要强调了如何考虑针对 Trp 代谢途径治疗主动脉疾病。从各种动物疾病模型中获得的越来越多的证据表明，KP 有助于血管疾病发展过程中的炎症过程，特别是动脉粥样硬化和动脉瘤的发展。这篇综述概述了当前对 Trp 代谢紊乱如何引发主动脉炎症和主动脉疾病表型的见解。我们还简要强调了如何考虑针对 Trp 代谢途径治疗主动脉疾病。