PTP4A3 plays an important role in the tumorigenesis and metastasis of multiple tumors, but its prognostic role in renal cancer is not well understood. We utilized the Oncomine and Tumor Immunoassay Resource databases to examine the differential expression of PTP4A3 in tumor tissues and normal tissues in breast, urinary tract, gastrointestinal tract and skin. Using the GEPIA and PrognoScan databases, the independent prognostic role of PTP4A3 was confirmed in clear cell renal cell cancer and papillary renal cell cancer. Expression of PTP4A3 were obviously higher in tumor tissue compare with normal tissues (P=0.028). We haven’t found the associations of PTP4A3 and clinicopathological features in our IHC cohort. Ectopic expression of PTP4A3 promotes proliferation, migration and invasion and increased the mRNA level of TGFB1 in RCC cell lines. Immunohistochemical staining indicated that the expression of PTP4A3 associates with CD3+ (P =0.037)/CD8+ (P =0.037) intratumor TILs, not with invasive margins in renal cancer. Comprehensive analysis of immune infiltration in the TIMER database correlated PTP4A3 expression with the infiltration of B cells, CD8+ T cells, CD4+ T cells and neutrophils in both clear cell renal cell carcinoma and papillary renal cell carcinoma. PTP4A3 expression was associated with the infiltration of dendritic cells in papillary renal cell carcinoma. We further confirmed that the infiltration of B cells and CD8+ T cells was associated with poor prognosis in papillary renal cell carcinoma patients, consistent with the prognostic role of PTP4A3 in papillary renal cell carcinoma. PTP4A3 expression correlated genes involved in B cells, monocytes, M1 macrophages, Th2 and Treg cells in papillary renal cell carcinoma. These results suggest PTP4A3 as a prognostic factor with a role in regulating immune cell infiltration in papillary renal cell carcinoma.

PTP4A3在多种肿瘤的发生和转移中起重要作用，但其在肾癌中的预后作用尚不清楚。我们利用 Oncomine 和肿瘤免疫测定资源数据库来检查 PTP4A3 在乳腺、泌尿道、胃肠道和皮肤的肿瘤组织和正常组织中的差异表达。使用 GEPIA 和 PrognoScan 数据库，证实了 PTP4A3 在透明细胞肾细胞癌和乳头状肾细胞癌中的独立预后作用。PTP4A3在肿瘤组织中的表达明显高于正常组织（磷=0.028）。我们尚未在 IHC 队列中发现 PTP4A3 与临床病理特征的关联。PTP4A3 的异位表达促进增殖、迁移和侵袭，并增加 RCC 细胞系中 TGFB1 的 mRNA 水平。免疫组化染色表明 PTP4A3 的表达与 CD3+ 相关（磷 =0.037)/CD8+ (磷=0.037) 肿瘤内 TIL，在肾癌中不具有浸润性边缘。TIMER 数据库中免疫浸润的综合分析将 PTP4A3 表达与透明细胞肾细胞癌和乳头状肾细胞癌中 B 细胞、CD8+ T 细胞、CD4+ T 细胞和中性粒细胞的浸润相关联。PTP4A3 表达与乳头状肾细胞癌中树突状细胞的浸润有关。我们进一步证实 B 细胞和 CD8+ T 细胞的浸润与乳头状肾细胞癌患者的不良预后相关，这与 PTP4A3 在乳头状肾细胞癌中的预后作用一致。PTP4A3表达与乳头状肾细胞癌中B细胞、单核细胞、M1巨噬细胞、Th2和Treg细胞相关基因。