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The Role of B Cells in Adult and Paediatric Liver Injury
Frontiers in Immunology ( IF 7.3 ) Pub Date : 2021-09-23 , DOI: 10.3389/fimmu.2021.729143
Arzoo M Patel 1 , Yuxin S Liu 1, 2 , Scott P Davies 1 , Rachel M Brown 3 , Deirdre A Kelly 4 , Dagmar Scheel-Toellner 2 , Gary M Reynolds 1, 4 , Zania Stamataki 1
Affiliation  

B lymphocytes are multitasking cells that direct the immune response by producing pro- or anti-inflammatory cytokines, by presenting processed antigen for T cell activation and co-stimulation, and by turning into antibody-secreting cells. These functions are important to control infection in the liver but can also exacerbate tissue damage and fibrosis as part of persistent inflammation that can lead to end stage disease requiring a transplant. In transplantation, immunosuppression increases the incidence of lymphoma and often this is of B cell origin. In this review we bring together information on liver B cell biology from different liver diseases, including alcohol-related and metabolic fatty liver disease, autoimmune hepatitis, primary biliary and primary sclerosing cholangitis, viral hepatitis and, in infants, biliary atresia. We also discuss the impact of B cell depletion therapy in the liver setting. Taken together, our analysis shows that B cells are important in the pathogenesis of liver diseases and that further research is necessary to fully characterise the human liver B cell compartment.



中文翻译:

B 细胞在成人和儿童肝损伤中的作用

B 淋巴细胞是多任务细胞,通过产生促炎或抗炎细胞因子、呈递用于 T 细胞激活和共刺激的加工抗原以及转化为抗体分泌细胞来指导免疫反应。这些功能对于控制肝脏感染很重要,但也可能加剧组织损伤和纤维化,这是持续炎症的一部分,可能导致需要移植的终末期疾病。在移植过程中,免疫抑制会增加淋巴瘤的发病率,并且通常是 B 细胞起源的。在这篇综述中,我们汇集了不同肝脏疾病的肝 B 细胞生物学信息,包括酒精相关性和代谢性脂肪肝病、自身免疫性肝炎、原发性胆汁性和原发性硬化性胆管炎、病毒性肝炎以及婴儿胆道闭锁。我们还讨论了 B 细胞耗竭疗法对肝脏的影响。总而言之,我们的分析表明 B 细胞在肝脏疾病的发病机制中很重要,需要进一步的研究来全面表征人类肝脏 B 细胞区室。

更新日期:2021-09-23
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