Herein, we describe a high-performance electrochemical sensor for the detection of regorafenib (REG) using bimetallic Pd–Ru nanoparticles anchored on pomegranate peel extract (PPE) derived reduced graphene oxide (Pd–Ru/rGO). PPE was employed to neutralize the extremely acid acidic graphene then cast-off along with the metal precursor for the duration of the chemical reduction to accomplish well dispersed Pd–Ru nanoparticles. Bimetallic Pd–Ru/rGO nanocomposites were synthesized using a facile chemical reduction method. Under optimal conditions, based on the differential pulse voltammetric studies it has been confirmed that the fabricated sensors has good electrocatalytic activity toward the detection of REG, spanning over the linear dynamic range of 0.5–300 nM. Moreover, the sensor exhibited a low limit of detection of 1.6 nM and a limit of quantification of 4.8 nM. The electrochemical sensor unveiled admirable selectivity and sensitivity, reproducibility, and repeatability. The fabricated sensor was suitable for real sample analysis (pharmaceutical tablet, human blood plasm, wastewater) with satisfactory recovery. The strategy presented herein can be employed in the development of electrochemical sensors for other target analytes.

在此，我们描述了一种用于检测瑞戈非尼 (REG) 的高性能电化学传感器，该传感器使用固定在石榴皮提取物 (PPE) 衍生的还原氧化石墨烯 (Pd-Ru/rGO) 上的双金属 Pd-Ru 纳米粒子。PPE 被用来中和极酸的酸性石墨烯，然后在化学还原过程中与金属前体一起丢弃，以实现良好分散的 Pd-Ru 纳米颗粒。使用简便的化学还原方法合成了双金属 Pd-Ru/rGO 纳米复合材料。在最佳条件下，基于差分脉冲伏安法研究已经证实，所制造的传感器对 REG 的检测具有良好的电催化活性，跨越 0.5-300 nM 的线性动态范围。此外，该传感器的检测下限为 1。6 nM 和 4.8 nM 的量化限制。电化学传感器展示了令人钦佩的选择性和灵敏度、再现性和可重复性。所制造的传感器适用于实际样品分析（药片、人体血浆、废水），回收率令人满意。本文提出的策略可用于开发用于其他目标分析物的电化学传感器。