Adolescents and young adults (AYAs) at risk of primary ovarian insufficiency (POI) often request fertility preservation consultation. We report consult/treatment outcomes for 21 cancer survivors and 3 mosaic Turner syndrome (TS) patients (mean age 21.6 at consult, 3 with POI). Ten AYAs (9 survivors, 1 mosaic TS) attempted ovarian stimulation; 4 cancelled for poor response. Of completed cycles, mean 3.8 mature oocytes were retrieved, with mean anti-Müllerian hormone 0.653 ng/mL. Ovarian stimulation for mosaic TS AYA and survivors is possible, even with diminished ovarian reserve. Further study is needed to establish guidelines for patient selection, treatment timing, and stimulation protocols.

中文翻译：

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因癌症治疗史或马赛克特纳综合征而有原发性卵巢功能不全风险的女性的生育力保留咨询结果

有原发性卵巢功能不全 (POI) 风险的青少年和年轻人 (AYA) 经常要求生育保留咨询。我们报告了 21 名癌症幸存者和 3 名马赛克特纳综合征 (TS) 患者的咨询/治疗结果（咨询时平均年龄 21.6 岁，3 名患有 POI）。10 名 AYA（9 名幸存者，1 名马赛克 TS）尝试卵巢刺激；4 因反应不佳而取消。在完成的周期中，平均回收了 3.8 个成熟卵母细胞，平均抗苗勒管激素为 0.653 ng/mL。即使卵巢储备减少，马赛克 TS AYA 和幸存者的卵巢刺激也是可能的。需要进一步研究以确定患者选择、治疗时机和刺激方案的指南。