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Smart Nanozyme Platform with Activity-Correlated Ratiometric Molecular Imaging for Predicting Therapeutic Effects
Angewandte Chemie International Edition ( IF 16.6 ) Pub Date : 2021-09-23 , DOI: 10.1002/anie.202110427
Lili Teng 1 , Xiaoyu Han 1 , Yongchao Liu 1 , Chang Lu 1 , Baoli Yin 1 , Shuangyan Huan 1 , Xia Yin 1 , Xiao-Bing Zhang 1 , Guosheng Song 1
Affiliation  

A manganese-semiconducting polymer-based nanozyme (MSPN) is developed for real-time reporting the catalytic activity of itself in acid-activated cancer therapy by ratiometric near-infrared fluorescence (NIRF)-photoacoustic (PA) molecular imaging. The nanoplatform can self-monitor the activation of nanozymes during cancer therapy, which has potential to predict therapeutic effects in vivo and guide nanoenzymes in personalized cancer treatment.
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中文翻译:

具有活性相关比率分子成像的智能纳米酶平台,用于预测治疗效果

开发了一种基于锰半导体聚合物的纳米酶 (MSPN),用于通过比率近红外荧光 (NIRF)-光声 (PA) 分子成像实时报告自身在酸激活癌症治疗中的催化活性。纳米平台可以在癌症治疗过程中自我监测纳米酶的激活,这具有预测体内治疗效果并指导纳米酶进行个性化癌症治疗的潜力。
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更新日期:2021-11-30
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