Gold nanoparticles have been widely investigated for biomedical applications due to their optical properties. These particles present the interesting feature of absorbing light when stimulated with laser radiation to generate heating. Among the possible morphologies for synthetic gold nanoparticles, gold nanorods have properties of great interest for applications in the photohyperthermia processes. Due to their morphology, gold nanorods can absorb light at longer wavelengths comprising specific regions of the electromagnetic spectrum, such as the region of the biological window, in which laser radiation has less interaction with tissues. However, these nanoparticles present limitations in biomedical applications, such as low colloidal and thermal stabilities that can be overcome by coating the gold nanorods with silica MCM-41. The silicate covering can provide greater stability for gold nanorods and allow multifunctionality in treating different diseases through photohyperthermia. This work developed a specific chemical route through seed and growth solutions to synthesize gold nanorods with controlled particle size, rod morphology, and silica covering for photohyperthermia applications. The synthesized samples were characterized through a multi-technique approach that successfully demonstrated the presence of gold nanorods inside the silica coating, presenting high stability and desirable textural and morphological characteristics for bioapplications. Furthermore, silica-coated gold nanorods exhibit high biocompatibility and great performance in generating therapeutic heating by absorbing laser radiation in the biological window range, making the system developed in this work a promising agent in photohyperthermia.

由于其光学特性，金纳米粒子已被广泛研究用于生物医学应用。当用激光辐射刺激产生热量时，这些粒子呈现出吸收光的有趣特征。在合成金纳米粒子的可能形态中，金纳米棒具有在光热疗过程中应用的重要特性。由于它们的形态，金纳米棒可以吸收较长波长的光，包括电磁波谱的特定区域，例如生物窗口区域，其中激光辐射与组织的相互作用较少。然而，这些纳米粒子在生物医学应用中存在局限性，例如可以通过用二氧化硅 MCM-41 涂覆金纳米棒来克服低胶体和热稳定性。硅酸盐覆盖物可以为金纳米棒提供更大的稳定性，并允许通过光热疗法治疗不同疾病的多功能性。这项工作开发了一种特定的化学途径，通过种子和生长溶液合成具有受控粒度、棒形貌和二氧化硅覆盖的金纳米棒，用于光热应用。合成的样品通过多种技术方法进行表征，该方法成功地证明了二氧化硅涂层内部存在金纳米棒，具有高稳定性和生物应用所需的纹理和形态特征。此外，二氧化硅包覆的金纳米棒通过吸收生物窗口范围内的激光辐射，表现出高生物相容性和良好的治疗加热性能，