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Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer
Inflammation Research ( IF 6.7 ) Pub Date : 2021-09-21 , DOI: 10.1007/s00011-021-01501-x
Hang Yang 1 , Bin Wei 2 , Bing Hu 1
Affiliation  

Objective

Helicobacter pylori (H. pylori) infects approximately half of the world’s population, as one of the most common chronic infections. H. pylori infection has been widely recognized as a major risk factor for gastric cancer (GC).

Methods

Eradication treatment is considered to abolish the inflammatory response and prevent progression to GC. However, only 1–3% of H. pylori-infected patients develop GC, whereas GC can occur even after eradicating H. pylori. In addition, the incidence of GC following H. pylori infection is significantly higher compared to the gross incidence induced by all causes, although eradicating H. pylori reduces the risk of developing GC.

Results

Therefore, it is reasonable to hypothesize that H. pylori infection results in changes that persist even after its eradication. Several of these changes may not be reversible within a short time, including the status of inflammation, the dysfunction of immunity and apoptosis, mitochondrial changes, aging and gastric dysbacteriosis.

Conclusion

The present review article aimed to discuss these potential long-lasting changes induced by H. pylori infection that may follow the eradication of H. pylori and contribute to the development of GC.



中文翻译:

幽门螺杆菌感染后胃黏膜的慢性炎症和持久变化与胃癌有关

客观的

 作为最常见的慢性感染之一,幽门螺杆菌 (H. pylori)感染了世界上大约一半的人口。H. pylori感染已被广泛认为是胃癌 (GC) 的主要危险因素。

方法

根除治疗被认为可以消除炎症反应并防止进展为 GC。然而,只有 1-3% 的H. pylori感染患者会发生 GC,而即使在根除H. pylori后也会发生 GC 。此外,与所有原因引起的总发病率相比,H. pylori感染后 GC 的发生率明显更高,尽管根除H. pylori会降低发生 GC 的风险。

结果

因此,假设H. pylori感染导致即使在其根除后仍持续存在的变化是合理的。其中一些变化可能在短时间内不可逆,包括炎症状态、免疫功能障碍和细胞凋亡、线粒体变化、衰老和胃菌群失调。

结论

本综述文章旨在讨论由H. pylori感染引起的这些潜在的长期变化,这些变化可能在H. pylori根除后并有助于 GC 的发展。

更新日期:2021-09-22
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