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In Vitro Acetylcholinesterase Inhibitory and Antioxidant Activity of Alphonsea tonkinensis A.DC
Natural Product Communications ( IF 1.8 ) Pub Date : 2021-09-22 , DOI: 10.1177/1934578x211042134
Khan Viet Nguyen 1, 2 , Thu Oanh Thi Nguyen 1 , Duc Viet Ho 1 , Jyrki Heinämäki 2 , Ain Raal 2 , Hoai Thi Nguyen 1
Affiliation  

Knowledge of the bioactivity of Alphonsea tonkinensis A.DC is limited. We have investigated the in vitro acetylcholinesterase inhibitory and antioxidant activities of extracts and pure compounds isolated from stems and leaves of this species collected from Dakrong district, Quang Tri Province, Vietnam. Extracts and isolated compounds were obtained by using an in-house extraction and chromatographic technique. The in vitro acetylcholinesterase inhibitory and antioxidant activities were evaluated using an Ellman test and 2,2-diphenyl-1-picryl-hydrazyl test, respectively. The total MeOH and CH2Cl2 extracts, the MeOH portion of the CH2Cl2 extract, pseudocolumbamine, and pseudopalmatine showed potential inhibitory activity against acetylcholinesterase with IC50 values of 22.7, 32.9, 14.6, 18.9, and 8.6 μM, respectively. The aqueous phase (pH 9), MeOH portion of the CH2Cl2 extract, and N-trans-feruloyltyramin exhibited significant antioxidant activities with IC50 values of 24.5, 72.1, and 61.2 µM, respectively. This is the first study showing such bioactivities of various extracts obtained from A. tonkinensis.



中文翻译:

Alphonsea tonkinensis A.DC 的体外乙酰胆碱酯酶抑制和抗氧化活性

Alphonsea tonkinensis A.DC生物活性的了解是有限的。我们研究了从越南广治省 Dakrong 区收集的该物种的茎和叶中分离的提取物和纯化合物的体外乙酰胆碱酯酶抑制和抗氧化活性。提取物和分离的化合物是通过使用内部提取和色谱技术获得的。体外乙酰胆碱酯酶抑制和抗氧化活性分别使用 Ellman 试验和 2,2-diphenyl-1-picryl-hydrazyl 试验进行评估。总MeOH和CH 22倍的提取物,该CH的MeOH中部分22提取物、pseudocolumbamine 和pseudopalmatine 对乙酰胆碱酯酶显示出潜在的抑制活性,IC 50值分别为 22.7、32.9、14.6、18.9 和 8.6 μM。水相 (pH 9)、CH 2 Cl 2提取物的甲醇部分和N -反式阿魏酰酪胺表现出显着的抗氧化活性,IC 50值分别为24.5、72.1和 61.2 µM。这是第一项显示从A. tonkinensis获得的各种提取物具有此类生物活性的研究。

更新日期:2021-09-22
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