Natural Product Communications ( IF 1.8 ) Pub Date : 2021-09-22 , DOI: 10.1177/1934578x211045808 Le Nhat Thuy Giang 1, 2 , Dang Thi Tuyet Anh 1, 2 , Hoang Thi Phuong 1 , Nguyen Ha Thanh 1, 2 , Nguyen Thi Quynh Giang 1 , Nguyen Tuan Anh 1 , Nguyen Van Tuyen 1, 2 , Phan Van Kiem 2, 3
For the first time the 4-dimethylaminopyridine (DMAP) catalyzed straightforward and efficient procedure has been developed for the synthesis of 3,3′-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives starting from lawsone (2-hydroxy-1,4-naphthoquinone) and a variety of (hetero)aromatic aldehydes in ethanol under microwave irradiation. Three of nine synthesized compounds are new. This method provides notable advantages over existing procedures including use of non-traditional basic catalyst and environmentally benign solvent, mild reaction conditions, excellent yields, short reaction time and simple workup.
中文翻译:
DMAP 催化合成 3,3'-(芳基亚甲基)双(2-羟基萘-1,4-二酮)衍生物的高效便捷方法
首次的4-二甲基氨基吡啶(DMAP)催化的直接的和为3,3'的合成效率的程序已被开发- (芳基亚甲基)双(2-羟基萘-1,4-二酮)从开始指甲花醌衍生物(2-羟基-1,4-萘醌)和乙醇中的各种(杂)芳香醛在微波辐射下。九种合成化合物中的三种是新的。该方法与现有方法相比具有显着优势,包括使用非传统碱性催化剂和环境友好的溶剂,反应条件温和,收率高,反应时间短,后处理简单。