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Feasibility of Aerobic Exercise and Tai-Chi Interventions in Advanced Lung Cancer Patients: A Randomized Controlled Trial
Integrative Cancer Therapies ( IF 2.9 ) Pub Date : 2021-09-22 , DOI: 10.1177/15347354211033352
Denise Shuk Ting Cheung 1 , Naomi Takemura 1 , Tai Chung Lam 1, 2 , James Chung Man Ho 1 , Wen Deng 1 , Robert Smith 1 , Yinxia Yan 1 , Anne Wing Mui Lee 1, 2 , Chia Chin Lin 1, 3, 4
Affiliation  

Background

A majority of lung cancer patients are diagnosed at advanced stages. Although there is considerable evidence of the benefits of aerobic exercise and tai-chi for lung cancer patients, little is known about the comparative effectiveness of the 2 exercise modes in advanced lung cancer patients.

Objectives

To explore the feasibility and preliminary effects of aerobic exercise and tai-chi interventions on survival and well-being among advanced lung cancer patients.

Methods

In an assessor-blinded, exploratory randomized controlled trial, 30 advanced lung cancer patients were randomized to an aerobic exercise group, a tai-chi group (both attending 12-week, twice-weekly supervised sessions), or a self-management control group (receiving written exercise guidelines). The primary outcomes focused on feasibility including intervention completion, exercise adherence, and adverse events, while the secondary outcomes addressed preliminary effects and included 1-year survival, cancer symptoms (Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Score, Brief Fatigue Inventory), quality of life (EORTC QLQ-C30, QLQ-LC13), physical performance (6-minute walk test, up-and-go, sit-to-stand, 1-leg standing), activity levels (actigraph), and circadian rhythms (salivary cortisol).

Results

Intervention feasibility was established with a satisfactory completion rate at post-intervention for the aerobic exercise group (80%) and the tai-chi group (78%). The tai-chi group attained higher adherence than the exercise group in terms of attendance in supervised sessions (89% vs 75% of scheduled classes) and self-practice (225% vs 87% of the prescribed amount). Higher adherence to self-practice in the tai-chi group remained at the 6-month follow-up (81% vs 38% of the prescribed amount). No adverse event as a result of the intervention was reported. Effect-related outcomes did not show statistically significant changes in any group, except an improvement post-intervention in the up-and-go (−2.26, 95% CI: −4.04, −0.48) and sit-to-stand tests (4.52, 95% CI: 2.19, 6.85) in the aerobic exercise group.

Conclusions

The findings support the feasibility of aerobic exercise and tai-chi interventions in advanced lung cancer patients. A future study with a larger sample from multiple sites is recommended to confirm the comparative effects of the 2 exercise interventions relative to the self-management group and to enhance the generalizability of the findings.



中文翻译:

晚期肺癌患者有氧运动和太极干预的可行性:一项随机对照试验

背景

大多数肺癌患者在确诊时已是晚期。尽管有大量证据表明有氧运动和太极拳对肺癌患者有益,但对于晚期肺癌患者这两种运动方式的比较有效性知之甚少。

目标

探讨有氧运动和太极拳干预对晚期肺癌患者生存和幸福感的可行性和初步效果。

方法

在一项评估者盲法、探索性随机对照试验中,30 名晚期肺癌患者被随机分配到有氧运动组、太极拳组(均参加 12 周,每周两次的监督课程)或自我管理对照组(收到书面练习指南)。主要结果侧重于可行性,包括干预完成、运动依从性和不良事件,而次要结果涉及初步影响,包括 1 年生存率、癌症症状(匹兹堡睡眠质量指数、医院焦虑和抑郁评分、简要疲劳量表)、生活质量(EORTC QLQ-C30、QLQ-LC13)、身体机能(6 分钟步行测试、起立、坐立、单腿站立)、活动水平(actigraph)和昼夜节律(唾液皮质醇)。

结果

有氧运动组 (80%) 和太极拳组 (78%) 在干预后完成率令人满意,已确定干预可行性。在参加监督课程(89% 对 75% 预定课程)和自我练习(225% 对 87% 规定数量)方面,太极拳组的依从性高于运动组。在 6 个月的随访中,太极拳组对自我练习的依从性更高(规定量的 81% 对 38%)。没有报告干预导致的不良事件。效果相关的结果在任何组中都没有显示出统计学上的显着变化,除了在起立 (-2.26, 95% CI: -4.04, -0.48) 和坐到站测试 (4.52 , 95% CI: 2.19, 6.85) 在有氧运动组中。

结论

研究结果支持有氧运动和太极拳干预晚期肺癌患者的可行性。建议未来进行来自多个地点的更大样本的研究,以确认 2 种运动干预相对于自我管理组的比较效果,并增强研究结果的普遍性。

更新日期:2021-09-22
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