In this study, we synthesized new 1,2,4-triazolpyrimidoazepine derivatives in high yields using multicomponent reactions of isatins, alkyl bromides, activated acetylenic compounds, guanidine, aldehydes, and hydrazonoyl chloride in the presence of Fe₃O₄/CuO/ZnO@MWCNT as a high performance catalyst in water at room temperature. The Fe₃O₄/CuO/ZnO@MWCNT synthesizes using Petasites hybridus rhizome water extract as a green media and moderate base. As well Fe₃O₄/CuO/ZnO@MWCNT MNCs show a good improvement in the yield of the product and displayed significant reusable activity. Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst, and products separation.

中文翻译：

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Fe3O4/CuO/ZnO@MWCNT MNCs 作为一种高效的有机金属纳米催化剂促进了新型 1,2,4-三唑嘧啶并氮杂衍生物的合成：抗氧化和抗菌活性的研究

_{在这项研究中，我们在 Fe 3} O ₄ /CuO/ZnO存在下使用靛红、烷基溴、活化炔属化合物、胍、醛和肼酰氯的多组分反应，以高收率合成了新的 1,2,4-三唑嘧啶并氮杂卓衍生物。@MWCNT 作为室温下水中的高性能催化剂。Fe ₃ O ₄ /CuO/ZnO@MWCNT 使用Petasites hybridus根茎水提取物作为绿色培养基和适度碱合成。还有 Fe ₃ O ₄/CuO/ZnO@MWCNT MNCs 在产品收率方面表现出良好的提高，并表现出显着的可重复使用活性。本研究的另一个目的是利用二苯基苦肼 (DPPH) 的自由基捕获和铁还原能力实验研究合成化合物的抗氧化能力。此外，通过对革兰氏阳性菌和革兰氏阴性菌的纸片扩散试验证明了一些合成化合物的抗菌活性。该方法具有反应时间短、产品收率高、催化剂简单、产品分离等优点。