当前位置: X-MOL 学术BMJ Open Ophthalmol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Ocular manifestations of RT-PCR-confirmed COVID-19 cases in a large database cross-sectional study
BMJ Open Ophthalmology Pub Date : 2021-09-01 , DOI: 10.1136/bmjophth-2021-000775
Deepayan Sarkar 1 , Deepak Soni 1 , Aniza Nagpal 1 , Fazil Khurram 1 , Samendra Karkhur 1 , Vidhya Verma 1 , Rajiv R Mohan 2 , Bhavana Sharma 1
Affiliation  

Objective To evaluate ocular manifestations of reverse transcriptase (RT)-PCR-confirmed SARS-CoV-2-infected patients in a validated comparative model, and additionally to evaluate the correlation between severity of COVID-19 and ocular manifestations. Methods and Analysis In a prospective cross-sectional study, a total of 2400 subjects were enrolled over a period of 8 months. To eliminate bias of identical ocular symptom profile in other non-COVID-19 respiratory infections and to acquire a comparative model, 1200 COVID-19 RT-PCR-positive patients (group 1) and 1200 RT-PCR-negative patients (group 2) were included. Data collection included use of a prestructured tool and ‘Google-forms’, along with stratification of patients into ‘ mild, moderate, and severe’ categories. Study subjects were evaluated for ocular manifestations by clinical examination and laboratory work-up. Univariate and multivariate logistic regression analyses were performed. Results 144 (12%) patients in group 1 had ocular symptoms as compared with 24 (2%) patients in group 2 (p<0.001). Ocular manifestations (symptoms and signs) comprising burning sensation (6.7%, p<0.001), foreign body sensation and irritation (7.0%, p<0.001), and conjunctival signs (2.7%, p<0.001) were found statistically significant in group 1 as compared with group 2. Ocular involvement increased in proportion to severity of COVID-19: mild (5.3%), moderate (24.6%) and severe (58.8%) (p=0.0006). Conclusion The frequency of occurrence of ocular manifestations was higher in group 1 as opposed to group 2. Furthermore, the presence of ocular manifestations carried a direct correlation with severity of systemic disease and presence of comorbidities. Data sharing not applicable as no datasets generated and/or analysed for this study.

中文翻译:

大型数据库横断面研究中经 RT-PCR 确诊的 COVID-19 病例的眼部表现

目的 在经过验证的比较模型中评估经逆转录酶 (RT)-PCR 确诊的 SARS-CoV-2 感染患者的眼部表现,并另外评估 COVID-19 的严重程度与眼部表现之间的相关性。方法和分析 在一项前瞻性横断面研究中,共有 2400 名受试者在 8 个月的时间内被纳入。为了消除其他非 COVID-19 呼吸道感染中相同眼部症状特征的偏差并获得比较模型,1200 名 COVID-19 RT-PCR 阳性患者(第 1 组)和 1200 名 RT-PCR 阴性患者(第 2 组)被包括在内。数据收集包括使用预结构化工具和“谷歌表格”,以及将患者分为“轻度、中度和重度”类别。通过临床检查和实验室检查评估研究对象的眼部表现。进行了单变量和多变量逻辑回归分析。结果 第 1 组有 144 名 (12%) 患者有眼部症状,而第 2 组有 24 名 (2%) 患者有眼部症状 (p<0.001)。眼部表现(症状和体征)包括烧灼感(6.7%,p<0.001)、异物感和刺激(7.0%,p<0.001)和结膜体征(2.7%,p<0.001)在组中发现具有统计学意义1 与组 2 相比。眼部受累与 COVID-19 的严重程度成正比:轻度 (5.3%)、中度 (24.6%) 和重度 (58.8%) (p=0.0006)。结论 与第 2 组相比,第 1 组眼部症状的发生频率更高。此外,眼部表现的存在与全身性疾病的严重程度和合并症的存在直接相关。数据共享不适用,因为没有为本研究生成和/或分析数据集。
更新日期:2021-09-22
down
wechat
bug