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The Intestinal Dysbiosis of Mothers with Gestational Diabetes Mellitus (GDM) and Its Impact on the Gut Microbiota of Their Newborns
Canadian Journal of Infectious Diseases and Medical Microbiology ( IF 2.8 ) Pub Date : 2021-09-22 , DOI: 10.1155/2021/3044534
Xinke Li 1 , Da Yu 2 , Yushuang Wang 1 , Huimin Yuan 3 , Xixi Ning 1 , Binqi Rui 1 , Zengjie Lei 1 , Jieli Yuan 1 , Jingyu Yan 4 , Ming Li 1
Affiliation  

Gestational diabetes mellitus (GDM) is defined as “diagnosed as impaired glucose tolerance for the first time during pregnancy,” which can lead to adverse pregnancy outcomes and produces divergent effects on mothers and newborns. In recent years, with the continuous expansion of obese people, GDM shows an upward trend. The abundant and diverse members of the human gut microbiota exert critical roles in the maintenance of human health. Studies have shown that GDM may be associated with disordered gut microbiota in both mothers and newborns. Taking into account the potential effects on maternal and consequently neonatal health, in this review, we analyzed the available data and discussed the current knowledge about the potential relationship between GDM and intestinal dysbiosis in mothers and newborns. In addition, we also discussed the influencing factors derived from GDM mothers on the gut microbiome of their newborns, including the vertical transmission of microbiota from mothers, the alteration of milk components of GDM mothers, and using of probiotics. Hoping that new insights into the role of the gut microbiota in GDM could lead to the development of integrated strategies to prevent and treat these metabolic disorders.

中文翻译:

妊娠期糖尿病 (GDM) 母亲肠道菌群失调及其对新生儿肠道微生物群的影响

妊娠期糖尿病 (GDM) 被定义为“在怀孕期间首次被诊断为糖耐量受损”,这会导致不良妊娠结局并对母亲和新生儿产生不同的影响。近年来,随着肥胖人群的不断扩大,GDM呈上升趋势。人类肠道微生物群中丰富多样的成员在维持人类健康方面发挥着关键作用。研究表明,GDM 可能与母亲和新生儿的肠道微生物群紊乱有关。考虑到对孕产妇和新生儿健康的潜在影响,在本综述中,我们分析了可用数据并讨论了目前关于 GDM 与母亲和新生儿肠道生态失调之间潜在关系的知识。此外,我们还讨论了 GDM 母亲对新生儿肠道微生物群的影响因素,包括母亲微生物群的垂直传播、GDM 母亲乳汁成分的改变以及益生菌的使用。希望对肠道微生物群在 GDM 中的作用的新见解可以导致制定预防和治疗这些代谢紊乱的综合策略。
更新日期:2021-09-22
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