Breast cancer (BRCA) has severely threatened women’s health worldwide. Radiotherapy is a treatment for BRCA, which applies high doses of ionizing radiation to induce cancer cell death and reduce disease recurrence. Radioresistance is one of the most important elements that affect the therapeutic efficacy of radiotherapy. Long noncoding RNAs (lncRNAs) are suggested to dominate crucial roles in regulating the biological behavior of BRCA. Currently, some studies indicate that overexpression or inhibition of lncRNAs can greatly alter the radioresistance of BRCA. In this review, we summarized the knowledge on the classification and function of lncRNAs and the molecular mechanism of BRCA radioresistance, listed lncRNAs related to the BRCA radioresistance, highlighted their underlying mechanisms, and discussed the potential application of these lncRNAs in regulating BRCA radioresistance.

中文翻译：

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长链非编码 RNA 调控乳腺癌的放射抗性

乳腺癌（BRCA）严重威胁着全世界女性的健康。放射疗法是 BRCA 的一种治疗方法，它应用高剂量的电离辐射来诱导癌细胞死亡并减少疾病复发。放射抗性是影响放射治疗疗效的最重要因素之一。建议长链非编码 RNA (lncRNA) 在调节 BRCA 的生物学行为中起重要作用。目前，一些研究表明，lncRNAs的过表达或抑制可以极大地改变BRCA的放射抗性。在这篇综述中，我们总结了lncRNA的分类和功能以及BRCA抗辐射的分子机制方面的知识，列出了与BRCA抗辐射相关的lncRNA，强调了它们的潜在机制，