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Investigating Auditory Electrophysiological Measures of Participants with Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Event-Related Potential Studies
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-18 , DOI: 10.3233/jad-210556
Hadeel Y Tarawneh 1, 2 , Wilhelmina H A M Mulders 1 , Hamid R Sohrabi 3, 4, 5 , Ralph N Martins 4, 5 , Dona M P Jayakody 2, 6
Affiliation  

Abstract

Background:

Objectively measuring auditory functions has been proposed as an avenue in differentiating normal age-related cognitive dysfunction from Alzheimer’s disease (AD) and its prodromal states. Previous research has suggested auditory event-related potentials (AERPs) to be non-invasive, cost-effective, and efficient biomarkers for the diagnosis of AD.

Objective:

The objective of this paper is to review the published literature on AERPs measures in older adults diagnosed with AD and those at higher risk of developing AD, i.e., mild cognitive impairment (MCI) and subjective cognitive decline.

Methods:

The search was performed on six major electronic databases (Ovid MEDLINE, OVID EMBASE, PsycINFO, PubMed, Scopus, and CINAHL Plus). Articles identified prior to 7 May 2019 were considered for this review. A random effects meta-analysis and analysis of between study heterogeneity was conducted using the Comprehensive Meta-Analysis software.

Results:

The search identified 1,076 articles; 74 articles met the full inclusion criteria and were included in the systematic review, and 47 articles were included into the analyses. Pooled analysis suggests that AD participants can be differentiated from controls due to significant delays in ABR, N100, P200, N200, and P300 latencies. P300 amplitude was significantly smaller in AD participants compared to controls. P300 latencies differed significantly between MCI participants and controls based on the pooled analysis.

Conclusion:

The findings of this review indicate that some AERPs may be valuable biomarkers of AD. In conjunction with currently available clinical and neuropsychological assessments, AERPs can aid in screening and diagnosis of prodromal AD.



中文翻译:

调查轻度认知障碍和阿尔茨海默病参与者的听觉电生理测量:事件相关电位研究的系统评价和元分析

摘要

背景:

客观地测量听觉功能已被提议作为区分正常年龄相关认知功能障碍与阿尔茨海默病 (AD) 及其前驱状态的途径。先前的研究表明,听觉事件相关电位 (AERP) 是用于诊断 AD 的非侵入性、经济高效且有效的生物标志物。

客观的:

本文的目的是回顾已发表的关于被诊断患有 AD 的老年人和患 AD 风险较高的老年人(即轻度认知障碍 (MCI) 和主观认知能力下降)的 AERP 测量的文献。

方法:

搜索是在六个主要电子数据库(Ovid MEDLINE、OVID EMBASE、PsycINFO、PubMed、Scopus 和 CINAHL Plus)上进行的。本次审查考虑了 2019 年 5 月 7 日之前确定的文章。使用综合荟萃分析软件进行随机效应荟萃分析和研究之间的异质性分析。

结果:

搜索确定了 1,076 篇文章;74 篇文章符合完全纳入标准并被纳入系统评价,47 篇文章被纳入分析。汇总分析表明,由于 ABR、N100、P200、N200 和 P300 延迟的显着延迟,可以将 AD 参与者与对照组区分开来。与对照组相比,AD 参与者的 P300 幅度明显更小。根据汇总分析,MCI 参与者和对照组之间的 P300 延迟显着不同。

结论:

本综述的结果表明,一些 AERP 可能是 AD 的有价值的生物标志物。结合目前可用的临床和神经心理学评估,AERP 可以帮助筛查和诊断前驱 AD。

更新日期:2021-09-22
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