Abstract

A new multistage synthesis of the N-borylated dipeptide B₁₂-PheGlyOH has been proposed. The approach is based on the reaction of nucleophilic addition of amino acid derivatives to the [B₁₂H₁₁NCCH₃]^– anion. The products of each stage have been characterized by multinuclear NMR spectroscopy, IR absorption spectroscopy, and ESI mass spectrometry.

中文翻译：

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基于近十二硼酸阴离子的乙腈衍生物合成取代的N-硼酸化二肽的新方法

摘要

已经提出了一种新的 N-硼酸化二肽 B ₁₂ -PheGlyOH 的多阶段合成方法。该方法基于氨基酸衍生物与 [B ₁₂ H ₁₁ NCCH ₃ ] ^-阴离子的亲核加成反应。每个阶段的产物都已通过多核核磁共振光谱、红外吸收光谱和 ESI 质谱进行表征。