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Developing Actively Targeted Nanoparticles to Fight Cancer: Focus on Italian Research
Pharmaceutics ( IF 5.4 ) Pub Date : 2021-09-22 , DOI: 10.3390/pharmaceutics13101538
Monica Argenziano 1 , Silvia Arpicco 1 , Paola Brusa 1 , Roberta Cavalli 1 , Daniela Chirio 1 , Franco Dosio 1 , Marina Gallarate 1 , Elena Peira 1 , Barbara Stella 1 , Elena Ugazio 1
Affiliation  

Active targeting is a valuable and promising approach with which to enhance the therapeutic efficacy of nanodelivery systems, and the development of tumor-targeted nanoparticles has therefore attracted much research attention. In this field, the research carried out in Italian Pharmaceutical Technology academic groups has been focused on the development of actively targeted nanosystems using a multidisciplinary approach. To highlight these efforts, this review reports a thorough description of the last 10 years of Italian research results on the development of actively targeted nanoparticles to direct drugs towards different receptors that are overexpressed on cancer cells or in the tumor microenvironment. In particular, the review discusses polymeric nanocarriers, liposomes, lipoplexes, niosomes, solid lipid nanoparticles, squalene nanoassemblies and nanobubbles. For each nanocarrier, the main ligands, conjugation strategies and target receptors are described. The literature indicates that polymeric nanoparticles and liposomes stand out as key tools for improving specific drug delivery to the site of action. In addition, solid lipid nanoparticles, squalene nanoparticles and nanobubbles have also been successfully proposed. Taken together, these strategies all offer many platforms for the design of nanocarriers that are suitable for future clinical translation.

中文翻译:

开发主动靶向纳米粒子以对抗癌症:专注于意大利研究

主动靶向是一种提高纳米递送系统治疗效果的有价值且有前景的方法,因此开发肿瘤靶向纳米颗粒引起了广泛的研究关注。在该领域,意大利制药技术学术团体开展的研究一直专注于使用多学科方法开发主动靶向纳米系统。为了突出这些努力,本综述全面描述了意大利过去 10 年的研究成果,这些成果涉及开发主动靶向纳米颗粒以将药物引导至在癌细胞或肿瘤微环境中过度表达的不同受体。特别是,该评论讨论了聚合物纳米载体、脂质体、脂质复合物、niosomes、固体脂质纳米颗粒、角鲨烯纳米组件和纳米气泡。对于每个纳米载体,描述了主要配体、缀合策略和目标受体。文献表明,聚合物纳米颗粒和脂质体是改善特定药物向作用部位输送的关键工具。此外,固体脂质纳米粒、角鲨烯纳米粒和纳米气泡也被成功提出。总之,这些策略都为设计适合未来临床转化的纳米载体提供了许多平台。角鲨烯纳米颗粒和纳米气泡也已被成功提出。总之,这些策略都为设计适合未来临床转化的纳米载体提供了许多平台。角鲨烯纳米颗粒和纳米气泡也已被成功提出。总之,这些策略都为设计适合未来临床转化的纳米载体提供了许多平台。
更新日期:2021-09-22
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