A striking feature of chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection. The objective of this research was to examine oxidative stress in non-smoker and ex-smoker COPD subjects and its relationship to pulmonary functions and sputum cytology. This case control-study enrolled 40 patients with COPD who are non-smokers or ex-smokers and 30 healthy controls of non-smokers or ex-smokers; oxidative stress markers, superoxide dismutase (SOD), and malondialdehyde (MDA) were compared in the two groups. All oxidative stress markers are elevated in the COPD group versus the control group. MDA has a negative correlation with FEV1and dyspnea grade. Blood concentrations of SOD and MDA are consistently higher in patients with non-smokers or ex-smoker COPD when compared to non-smokers or ex-smoker healthy controls.

中文翻译：

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非吸烟者的慢性阻塞性肺疾病：氧化应激的作用

慢性阻塞性肺疾病 (COPD) 的一个显着特征是其在香烟烟雾暴露结束后无法解决，这导致该疾病也可能由其他内源性原因驱动，例如自身免疫或慢性感染。本研究的目的是检查非吸烟者和戒烟者 COPD 受试者的氧化应激及其与肺功能和痰细胞学的关系。本病例对照研究招募了 40 名不吸烟或曾吸烟的 COPD 患者和 30 名不吸烟或曾吸烟的健康对照者；比较两组氧化应激标志物、超氧化物歧化酶（SOD）和丙二醛（MDA）。与对照组相比，COPD 组的所有氧化应激标志物均升高。MDA与FEV1和呼吸困难分级呈负相关。