The FcγRs genotypes have been reported to play a key role in the defence against malaria parasites through both cellular and humoral immunity. This study aimed to investigate the possible correlation between FcγR (IIa, IIIa, and IIIb) genes polymorphism and the clinical outcome for anti‐malarial antibody response of Plasmodium falciparum infection among Saudi children. A total of 600 volunteers were enrolled in this study, including 200 malaria-free control (MFC) subjects, 218 patients with uncomplicated malaria (UM) and 182 patients with severe malaria (SM). The FcγR genotypes were analysed using PCR amplification methods, and measurements of immunoglobulin were determined using enzyme-linked immunosorbent assay (ELISA) technique. The data revealed that the FcγRIIa-R/R131 showed a statistically significant association with SM patients when compared to UM patients. Furthermore, higher levels of IgG1, IgG2, and IgG4 were associated with the FcγRIIa-H/H131 genotype among UM patients. Although the FcγRIIa-F/V176 genotype was not associated with UM, it showed a significant association with severe malaria. Interestingly, the FcγRIIIa-V/V176 genotype offered protection against SM. Moreover, SM patients carrying the FcγRIIIa-F/F genotype showed higher levels of AMA-1-specific IgG2 and IgG4 antibodies. The FcγRIIIb-NA1/NA1 and FcγRIIIb-NA2/NA2 genotypes did not show significant differences between the UM and the MFC groups. However, the genotype FcγRIIIb-NA2/NA2 was statistically significantly associated with SM patients. The data presented in this study suggest that the influence of the FcγRIIa-R/R131, FcγRIIIa-F/F176 and FcγRIIIb-NA2/NA2 genotypes are statistically significantly associated with SM patients. However, the FcγRIIa-H/H13 and FcγRIIIa-V/V176 genotypes have demonstrated a protective effect against SM when compared to UM patients. The impact of the FcyR (IIa, IIIa and IIIb) gene variants and anti-malaria IgG subclasses play an important role in susceptibility to malaria infection and disease outcome in Saudi children.

中文翻译：

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FcγRIIa、FcγRIIIa 和 FcγRIIIb 基因多态性和抗疟疾 IgG 亚类模式的显着差异与沙特儿童严重恶性疟原虫疟疾有关

据报道，FcγRs 基因型在通过细胞和体液免疫防御疟疾寄生虫方面发挥着关键作用。本研究旨在探讨 FcγR（IIa、IIIa 和 IIIb）基因多态性与沙特儿童恶性疟原虫感染的抗疟抗体反应的临床结果之间可能存在的相关性。本研究共招募了 600 名志愿者，包括 200 名无疟疾对照 (MFC) 受试者、218 名无并发症疟疾 (UM) 患者和 182 名重症疟疾 (SM) 患者。使用 PCR 扩增方法分析 FcγR 基因型，并使用酶联免疫吸附测定 (ELISA) 技术确定免疫球蛋白的测量值。数据显示，与 UM 患者相比，FcγRIIa-R/R131 显示出与 SM 患者的统计学显着关联。此外，较高水平的 IgG1、IgG2 和 IgG4 与 UM 患者的 FcγRIIa-H/H131 基因型相关。尽管 FcγRIIa-F/V176 基因型与 UM 无关，但它显示出与严重疟疾的显着关联。有趣的是，FcγRIIIa-V/V176 基因型提供了针对 SM 的保护。此外，携带 FcγRIIIa-F/F 基因型的 SM 患者显示出更高水平的 AMA-1 特异性 IgG2 和 IgG4 抗体。FcγRIIIb-NA1/NA1 和 FcγRIIIb-NA2/NA2 基因型在 UM 和 MFC 组之间没有显示显着差异。然而，基因型 FcγRIIIb-NA2/NA2 与 SM 患者在统计学上显着相关。本研究中提供的数据表明，FcγRIIa-R/R131、FcγRIIIa-F/F176 和 FcγRIIIb-NA2/NA2 基因型的影响与 SM 患者在统计学上显着相关。然而，与 UM 患者相比，FcγRIIa-H/H13 和 FcγRIIIa-V/V176 基因型已证明对 SM 具有保护作用。FcγR（IIa、IIIa 和 IIIb）基因变异体和抗疟疾 IgG 亚类的影响在沙特儿童对疟疾感染的易感性和疾病结果方面起着重要作用。