Acid-catalyzed tandem reactions of atropaldehyde acetals were established for the synthesis of three important molecules, 2,2-disubstituted indolin-3-ones, naphthofurans and stilbenes. The synthesis was realized using novel reaction cascades, which involved the same two initial steps: (i) S_N2′ substitution, in which the atropaldehyde acted as an electrophile; and (ii) oxidative cleavage of the carbon–carbon bond of the generated phenylacetaldehyde-type products. Compared with literature methods, the present protocol not only avoided the use of expensive noble metal catalysts, but also enabled a simple operation.

中文翻译：

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C-C键的酸催化裂解使阿托醛缩醛成为有机合成的掩蔽C2亲电试剂

阿托醛缩醛的酸催化串联反应被建立用于合成三个重要分子，2,2-二取代 indolin-3-ones、萘并呋喃和芪。该合成是使用新的反应级联反应实现的，其中涉及相同的两个初始步骤：(i) S _N 2' 取代，其中阿托醛充当亲电子试剂；(ii) 生成的苯乙醛类产物的碳-碳键的氧化裂解。与文献方法相比，本协议不仅避免使用昂贵的贵金属催化剂，而且操作简单。